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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
chronic toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
publication
Title:
Hygiene of labour
Author:
Zaugliikov S. D., Predtechenskiy M. B
Year:
1967
Bibliographic source:
Not specified

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
No information about the principles of method followed.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Isopropyl nitrate
EC Number:
216-983-6
EC Name:
Isopropyl nitrate
Cas Number:
1712-64-7
Molecular formula:
C3H7NO3
IUPAC Name:
propan-2-yl nitrate
Test material form:
liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Duration of treatment / exposure:
2 hours per day for 4 months
Frequency of treatment:
daily
Doses / concentrations
Dose / conc.:
0.25 mg/L air
Remarks:
The dose varies from 0.2 to 0.3 mg/L.
Control animals:
not specified

Results and discussion

Results of examinations

Clinical signs:
effects observed, treatment-related
Description (incidence and severity):
Low blood pressure
Mortality:
not specified
Body weight and weight changes:
not specified
Food consumption and compound intake (if feeding study):
not examined
Food efficiency:
not examined
Water consumption and compound intake (if drinking water study):
not specified
Ophthalmological findings:
not specified
Haematological findings:
effects observed, treatment-related
Description (incidence and severity):
Blood presure and haemoglobine reduced.
Clinical biochemistry findings:
not specified
Urinalysis findings:
not specified
Behaviour (functional findings):
not specified
Immunological findings:
not specified
Organ weight findings including organ / body weight ratios:
not specified
Gross pathological findings:
not specified
Neuropathological findings:
effects observed, treatment-related
Description (incidence and severity):
Deviations in the fuctioning of the central nervous system.
Histopathological findings: non-neoplastic:
not specified
Histopathological findings: neoplastic:
not specified
Other effects:
not specified

Effect levels

Dose descriptor:
NOAEL
Remarks on result:
not measured/tested

Target system / organ toxicity

Critical effects observed:
not specified
System:
central nervous system

Applicant's summary and conclusion

Conclusions:
Threshold limit value (TLV) for the Isopropyl Nitrate is 5 mg/m3.