Methyl dihydrogen phosphate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1994

Report date:

1994

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

no

GLP compliance:

yes

Test type:

fixed dose procedure

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Methyl dihydrogen phosphate

EC Number:

212-379-1

EC Name:

Methyl dihydrogen phosphate

Cas Number:

812-00-0

Molecular formula:

CH5O4P

IUPAC Name:

methyl dihydrogen phosphate

Test material form:

liquid

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

Single dose of 2.0 g/kg bw

No. of animals per sex per dose:

Five males and five females

Control animals:

no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

One female died on study Day 2

Clinical signs:

other: Piloerection, abnormal body carriage (hunched posture, abnormal gait (waddling), lethargy, decreased respiratory rate, partially closed eyelids, apllor of extremities, increased salivation, noisy respiration and walking on toes. Recovery was complete by D

Gross pathology:

No abnormalities noted at macroscopic examination.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The LD50 was found to be > 2.0 g/kg bw.

Executive summary:

Following a single oral dose of 2.0 g/kg bw test material, the LD50 was found to be > 2.0 g/kg bw.