Registration Dossier

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1994
Report date:
1994

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
no
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl dihydrogen phosphate
EC Number:
212-379-1
EC Name:
Methyl dihydrogen phosphate
Cas Number:
812-00-0
Molecular formula:
CH5O4P
IUPAC Name:
methyl dihydrogen phosphate
Test material form:
liquid

Test animals

Species:
rabbit
Strain:
New Zealand White
Remarks:
albino

Test system

Type of coverage:
semiocclusive
Preparation of test site:
clipped
Vehicle:
unchanged (no vehicle)
Controls:
other: untreated skin served as control
Amount / concentration applied:
0.5 mL
Duration of treatment / exposure:
4 hours
Observation period:
14 days
Number of animals:
Three

Results and discussion

In vivo

Results
Remarks on result:
other: severe dermal reactions with necrosis in all three animals

Applicant's summary and conclusion

Interpretation of results:
Category 1 (corrosive) based on GHS criteria
Conclusions:
Severe dermal irritation with necrosis were reported for all three animals tested.
Executive summary:

A single semi-occlusive application of the test item to intact rabbit skin for four hours elicited severe dermal irritation with necrosis.