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Administrative data

Endpoint:
relative self-ignition temperature (solids)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017-11-02 - 2017-11-03 (experimental phase)
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.16 (Relative Self-Ignition Temperature for Solids)
Version / remarks:
EU-Method A.16, of 30 May 2008 published on 31 May 2008, “Relative Self-Ignition Temperature for Solids“
Deviations:
yes
Remarks:
not affecting the validity / outcome of the study
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
3-[(aminoiminomethyl)thio]propanesulphonic acid
EC Number:
244-520-8
EC Name:
3-[(aminoiminomethyl)thio]propanesulphonic acid
Cas Number:
21668-81-5
Molecular formula:
C4H10N2O3S2
IUPAC Name:
3-(carbamimidoylsulfanyl)propane-1-sulfonic acid
Test material form:
solid: particulate/powder
Details on test material:
Storage: Room Temperature (20 ± 5°C), keep away from humidity
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: sponsor

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: The test item was stored in a tightly closed vessel at room temperature (15.8 – 22.5°C) under dry conditions in the dark.

Results and discussion

Relative self-ignition temperature (solids)
Key result
Remarks on result:
no self-ignition observed up to the melting point
Remarks:
The test item showed no self-ignition up to the melting range of 245.4 – 249.3 °C.

Applicant's summary and conclusion

Conclusions:
The auto-ignition temperature was determined in a GLP guideline study according to EU method A.16 without deviations on the registered substance itself. Hence, there is no indication given that the results are not reliable.
No increase in the temperature of the sample in comparison to that of the oven could be detected; also no signs of ignition could be observed.
The test item 3-[(Amino-iminomethyl)-thio]-1-propanesulphonic acid (UPS) is stated as “showing no self-ignition up to the melting range of 245.4 – 249.3 °C” under the test conditions.
No observations were made which might cause doubts concerning the validity of the study outcome.
Executive summary:

The auto-ignition temperature was determined in a GLP guideline study according to EU method A.16.The auto-flammability behaviour was determined by placing the test item into a stainless steel cube and heating from room temperature to an oven temperature of 250 °C with the ZPA-3 oven. No increase in the temperature of the sample in comparison to that of the oven could be detected, also no signs of ignition could be observed. Therefore, the test item 3-[(Amino-iminomethyl)-thio]-1-propanesulphonic acid (UPS) is stated as “showing no self-ignition up to the melting range of 245.4 – 249.3 °C” under the test conditions.

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