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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
2000

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
434-600-2
EC Name:
-
Cas Number:
2628-16-2
Molecular formula:
CH3CO2C6H4CH=CH2
IUPAC Name:
4-ethenylphenyl acetate
Test material form:
liquid

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Vehicle:
other: The test substance was applied as supplied
Amount / concentration applied:
537 mg (administered as 0.5 mL of test material)
Duration of treatment / exposure:
4 h
Number of animals:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Remarks:
(mean score 1)
Time point:
24/48/72 h
Score:
1.7
Reversibility:
fully reversible within: 16 days
Irritation parameter:
erythema score
Basis:
animal #2
Remarks:
(mean score 2)
Time point:
24/48/72 h
Score:
2
Reversibility:
fully reversible within: 16 days
Irritation parameter:
erythema score
Basis:
animal #3
Remarks:
(mean score 3)
Time point:
24/48/72 h
Score:
3
Reversibility:
fully reversible within: 16 days
Irritation parameter:
edema score
Basis:
animal #1
Remarks:
(mean score 1)
Time point:
24/48/72 h
Score:
2.7
Reversibility:
fully reversible within: 13 dyas
Irritation parameter:
edema score
Basis:
animal #2
Remarks:
(mean score 2)
Time point:
24/48/72 h
Score:
3.3
Reversibility:
fully reversible within: 13 days
Irritation parameter:
edema score
Basis:
animal #3
Remarks:
(mean score 3)
Time point:
24/48/72 h
Score:
3.3
Reversibility:
fully reversible within: 13 days
Irritant / corrosive response data:
Reversibility of any observed effect: Changes fully reversible within 16 days.
Other effects:
Very slight or slight erythema (score 1-2) and severe oedema (score 4) were observed in all animals one hour after bandage removal. At the 24 hour examination, slight or moderate erythema (score 2-3) and severe oedema (score 4) were evident. There was a gradual resolution of the oedema and erythema from 48 or 72 hour after bandage removal up to Day 13. The test sites of all animals were overtly normal on Day 16.

Any other information on results incl. tables

Maximum duration of erythema was 16 days and of oedema 13 days.

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Conclusions:
The mean erythema score over 3 animals in the time span 24-72h is 2.23.
The mean oedema score over 3 animals in the time span 24-72h is 3.10