Registration Dossier
Registration Dossier
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EC number: 221-411-3 | CAS number: 3087-37-4
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- The target substance is hydrolytically unstable with hydrolysis half-life less than 5 minute. The hydrolysis products include 1-propanol and hydrated titanium dioxide. The ecotoxicity data of the organic parts have been well-investigated and used for read-across.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- according to guideline
- Guideline:
- other: not specified
- Principles of method if other than guideline:
- not specified
- GLP compliance:
- not specified
- Analytical monitoring:
- no
- Test organisms (species):
- Chlorella pyrenoidosa
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 1 150 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Validity criteria fulfilled:
- yes
Referenceopen allclose all
Description of key information
Key value for chemical safety assessment
- EC10 or NOEC for freshwater algae:
- 1 150 mg/L
Additional information
No studies were conducted on the target substance, Titanium tetrapropanolate. As the target substance hydrolyses rapidly (half-life < 5 minutes) the intrinsic properties are related to hydrolysis products of the target substance.
On the basis that if entering the environmental, this substance will quickly dissociate to form the inorganic (poorly soluble) titanium dioxide and well-evaluated organic substances – 1-propanol.
The titanium dioxide is not considered further in this report as aquatic toxicity assessments do not apply.
Toxicity of 1-propanol to algae were tested on several species:Selenastrum capricornutum, Scenedesmus pannonicus, andChlorella pyrenoidosa. NOEC (48-96h) based growth rate values were 2000, 2900 and 1150 mg/l respectively. (Slooff et al. 1983). The lowest value of 1150 mg/l tested onChlorella pyrenoidosawere chosen for CSA.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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