Registration Dossier
Registration Dossier
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EC number: 221-411-3 | CAS number: 3087-37-4
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Effects of chronic ingestion of some lower aliphatic alcohols in rats.
- Author:
- Hillbom, ME; Franssila, K; Forsander, OA
- Year:
- 1 974
- Bibliographic source:
- Res Commun Chem Pathol Pharmacol. 1974 Sep;9(1):177-80
- Reference Type:
- secondary source
- Title:
- EU Risk Assessment Report, CAS No. 71-23-8: Propan-1-ol, Vol. 82
- Author:
- European Chemicals Bureau
- Year:
- 2 008
- Bibliographic source:
- EU Risk Assessment Report
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: other
- Principles of method if other than guideline:
- single dose
- GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- Propan-1-ol
- EC Number:
- 200-746-9
- EC Name:
- Propan-1-ol
- Cas Number:
- 71-23-8
- Molecular formula:
- C3H8O
- IUPAC Name:
- propan-2-ol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: drinking water
- Vehicle:
- water
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 4 months
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- no effects observed
Effect levels
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 3 000 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male
- Basis for effect level:
- clinical signs
Target system / organ toxicity
- Key result
- Critical effects observed:
- no
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
