Registration Dossier
Registration Dossier
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EC number: 215-559-8 | CAS number: 1331-61-9
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
The counter ion (ammonium) is not conisdered a potential sensitisation, so the assessment is based on other salts.
LAS IPA
In one dermal sensitization study with benzenesulfonic acid, 4-C10-13-sec-alkyl derivs.-, compd. with 2 -propanamine (97%), ten young adult Dunkin-Hartley guinea pigs were tested using the method of Magnusson and Kligmann. No cutaneous reaction attributable to allergy was recorded in animals from the treated group after the challenge phase, with the test item at 0.25% and 0.5%. Base on this result LAS IPA is not a dermal sensitizer.
LAS Na:
One test available examined the senistisation potential of LAS Na to the skin. 10 male and 10 female guinea pigs were given intradermal injections of 25% test solution. Control animals (5 male and 5 female) were given injections of vehicle only. One week later, a second induction was done by dermal exposure to 25% test solution for 24 hrs. Control animals were again exposed to vehicle only. On day 21, the challenge exposure was performed. All animals were exposed to 12.5% test solution dermally. Exposure was for 24 hrs, with observations made at 48 and 72 hrs after the start of exposure. No positive reactions were noted. The test substance is not sensitizing.
Migrated from Short description of key information:
One study is available examining the skin sensitisation potential of benzenesulfonic acid, 4-C10-13-sec-alkyl derivs.-, compd. with 2-propanamine (LAS IPA). The result of the study shows that the the substance is not a skin sensitiser.
Justification for selection of skin sensitisation endpoint:
This is the only study available examining the sensitisation potential of LAS IPA. It is a GLP, Guideline study, which fully addresses this endpoint requirement.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Data show that benzenesulfonic acid, 4-C10-13-sec-alkyl derivs.-, compd. with 2 -propanamine is not a dermal sensitiser and it shall not be classified and labeled as a skin sensitiser, according to the criteria laid down in CLP (EC) Regulation 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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