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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
October 9, 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
Deviations:
no
Qualifier:
according to guideline
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
Deviations:
no
Qualifier:
according to guideline
Guideline:
other: CIPAC MT 187
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
Laser scattering/diffraction
Type of particle tested:
primary particle
Type of distribution:
volumetric distribution
Key result
Percentile:
D10
Mean:
0.279 µm
St. dev.:
0.011
Key result
Percentile:
D50
Mean:
4.334 µm
St. dev.:
0.024
Key result
Percentile:
D90
Mean:
9.337 µm
St. dev.:
0.083
Key result
Percentile:
other: d3,4
Mean:
4.672 µm
St. dev.:
0.033

Table 1.Results of particle size distribution

Size

Test number and fraction size, [%]

1.

2.

3.

4.

5.

Average

Less than 2 µm

26.5

26.6

26.50

26.10

26.1

26.36

Less than 200 µm

100

100

100

100

100

100

d10[µm]

0.295

0.285

0.277

0.268

0.272

0.279

d50[µm]

4.347

4.311

4.308

4.338

4.364

4.334

d90[µm]

9.449

9.278

9.244

9.323

9.391

9.337

d4,3[µm]

4.713

4.646

4.636

4.664

4.699

4.672

Average *d4,3[µm]

4.67

SD [µm]

0.033

RSD [%]

0.71

*Average d4,3, [µm] – The mass moment mean (De Brouckere Mean Diameter)

Conclusions:
The average particle size for the test item is 0.279 µm (D10), 4.334 µm (D50), 9.337 µm (D90) and the mass moment mean (D4,3) is 4.672 µm.
Executive summary:

The particle size of the tested substance was determined using a Coulter  LS 13 320. The method used was in accordance with OECD guideline 110, CIPAC MT 187 and ISO 13320- 1, following GLP. The volumetric particle size distribution using the laser scattering method was recorded. The average particle size for the test item is 0.279 µm (D10), 4.334 µm (D50), 9.337 µm (D90) and the mass moment mean (D4,3) is 4.672 µm.

Description of key information

Key study: OECD 110. GLP study. The average particle size for the test item is 0.279 µm (D10), 4.334 µm (D50), 9.337 µm (D90) and the mass moment mean (D4,3) is 4.672 µm.

Additional information

Key study: The particle size of the tested substance was determined using a Coulter  LS 13 320. The method used was in accordance with OECD guideline 110, CIPAC MT 187 and ISO 13320- 1, following GLP. The volumetric particle size distribution using the laser scattering method was recorded. The average particle size for the test item is 0.279 µm (D10), 4.334 µm (D50), 9.337 µm (D90) and the mass moment mean (D4,3) is 4.672 µm.