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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
1. SOFTWARE : EPI-SUITE EPA (USA)

2. MODEL: ECOSAR v1.11

3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
CAS Number: 328-90-5
SMILES: OC(=O)C1=C(O)C=C(C=C1)C(F)(F)F

4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL: The QMRF is available in "Attached justification".

5. APPLICABILITY DOMAIN : The QPRF is available in 'Attached justification'.

6. ADEQUACY OF THE RESULT : The QPRF is available in 'Attached justification'.
Guideline:
other: REACH Guidance on QSARs R.6
Principles of method if other than guideline:
QSAR calculation by ECOSAR v1.1, EPA, USA (QSAR Prediction Reporting Format (QPRF) attached).
GLP compliance:
no
Specific details on test material used for the study:
- Smiles: OC(=O)C1=C(O)C=C(C=C1)C(F)(F)F
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
43.247 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Remarks on result:
other: calculated value.
Sublethal observations / clinical signs:

ECOSAR v1.11 predicted that the substance has a 96h-LC50 = 43.247 mg/L in fish.

Validity criteria fulfilled:
not applicable
Conclusions:
The calculated 96h-LC50 of the test item in fish is 43.247 mg/L.
Executive summary:

ECOSAR v1.11 calculation of the 96h-LC50 in fish was used. According to this method, the 96h-LC50 = 43.247 mg/L of test item in fish.

Description of key information

Key study: Internationally accepted method, ECOSAR, EPA (USA). The estimated 96h LC50 for fish is 43.247 mg/L (ECOSAR v1.11, phenols-acid class).

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
43.247 mg/L

Additional information