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Ecotoxicological information

Short-term toxicity to fish

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Reference
Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
1. SOFTWARE : EPI-SUITE EPA (USA)

2. MODEL: ECOSAR v1.11

3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
CAS Number: 328-90-5
SMILES: OC(=O)C1=C(O)C=C(C=C1)C(F)(F)F

4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL: The QMRF is available in "Attached justification".

5. APPLICABILITY DOMAIN : The QPRF is available in 'Attached justification'.

6. ADEQUACY OF THE RESULT : The QPRF is available in 'Attached justification'.
Guideline:
other: REACH Guidance on QSARs R.6
Principles of method if other than guideline:
QSAR calculation by ECOSAR v1.1, EPA, USA (QSAR Prediction Reporting Format (QPRF) attached).
GLP compliance:
no
Specific details on test material used for the study:
- Smiles: OC(=O)C1=C(O)C=C(C=C1)C(F)(F)F
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
43.247 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Remarks on result:
other: calculated value.
Sublethal observations / clinical signs:

ECOSAR v1.11 predicted that the substance has a 96h-LC50 = 43.247 mg/L in fish.

Validity criteria fulfilled:
not applicable
Conclusions:
The calculated 96h-LC50 of the test item in fish is 43.247 mg/L.
Executive summary:

ECOSAR v1.11 calculation of the 96h-LC50 in fish was used. According to this method, the 96h-LC50 = 43.247 mg/L of test item in fish.

Description of key information

Key study: Internationally accepted method, ECOSAR, EPA (USA). The estimated 96h LC50 for fish is 43.247 mg/L (ECOSAR v1.11, phenols-acid class).

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
43.247 mg/L

Additional information