Registration Dossier
Registration Dossier
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EC number: 700-368-9 | CAS number: 328-90-5
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- 1. SOFTWARE
: EPI-SUITE EPA (USA)
2. MODEL: ECOSAR v1.11
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
CAS Number: 328-90-5
SMILES: OC(=O)C1=C(O)C=C(C=C1)C(F)(F)F
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL: The QMRF is available in "Attached justification".
5. APPLICABILITY DOMAIN : The QPRF is available in 'Attached justification'.
6. ADEQUACY OF THE RESULT : The QPRF is available in 'Attached justification'. - Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- QSAR calculation by ECOSAR v1.1, EPA, USA (QSAR Prediction Reporting Format (QPRF) attached).
- GLP compliance:
- no
- Specific details on test material used for the study:
- - Smiles: OC(=O)C1=C(O)C=C(C=C1)C(F)(F)F
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 43.247 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: calculated value.
- Sublethal observations / clinical signs:
ECOSAR v1.11 predicted that the substance has a 96h-LC50 = 43.247 mg/L in fish.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The calculated 96h-LC50 of the test item in fish is 43.247 mg/L.
- Executive summary:
ECOSAR v1.11 calculation of the 96h-LC50 in fish was used. According to this method, the 96h-LC50 = 43.247 mg/L of test item in fish.
Reference
Description of key information
Key study: Internationally accepted method, ECOSAR, EPA (USA). The estimated 96h LC50 for fish is 43.247 mg/L (ECOSAR v1.11, phenols-acid class).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 43.247 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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