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Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Reference
Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
1. SOFTWARE
EPI-SUITE EPA (USA)

2. MODEL (incl. version number)
ECOSAR v1.11

3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
SMILES: c1cc(c(cc1C(F)(F)F)O)C(=O)O

4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
The QMRF is available in "Attached justification".

5. APPLICABILITY DOMAIN
The QPRF is available in "Attached justification".

6. ADEQUACY OF THE RESULT
The QPRF is available in "Attached justification".
Guideline:
other: REACH Guidance on QSARs R.6
Principles of method if other than guideline:
QSAR calculation by ECOSAR v1.11, EPA, USA (attached QSAR Prediction Reporting Format, QPRF).
GLP compliance:
no
Specific details on test material used for the study:
SMILES: c1cc(c(cc1C(F)(F)F)O)C(=O)O
Test organisms (species):
other: Green Algae
Key result
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
91.192 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Remarks on result:
other: ECOSAR predicted value
Details on results:
ECOSAR Class: Phenols-acid

ECOSAR v1.11 Class-specific Estimation (Phenols-acid) predicted that the test item has an LD50 (96h) = 91.192 mg/L for Green Algae.

Validity criteria fulfilled:
not applicable
Conclusions:
The estimated 96-h EC50 for algae and cyanobacteria is 91.192 mg/l (ECOSAR v1.11, phenols-acid).
Executive summary:

The estimated 96-h EC50 for algae and cyanobacteria is 91.192 mg/l (ECOSAR v1.11, phenols-acid).

Description of key information

Key study: Internationally accepted method, ECOSAR, EPA (USA). The estimated 96 -h EC50 for algae is 91.192 mg/l (ECOSAR v1.11, phenols-acid).

Key value for chemical safety assessment

EC50 for freshwater algae:
91.192 mg/L

Additional information