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EC number: 215-892-9
CAS number: 1445-45-0
The test for acute oral toxicity of
Trimethyl orthoacetate (TMOA) for rats (according to OECD 401 under GLP)
showed, that the liquid test substance led to no mortality in five male
and five female animals in a 14 -day limit test with a dose of 2000
mg/kg of bodyweight. No signs of systemic toxicity were observed during
the observation period. The test substance was applied orally (with a
rigid stomach tube) in a volume of 2.08 cm3/kg of bodyweight with an
exposure time of 24 hours.
The changes in bodyweight were normal for
all the animals.
Dissection at the end of the test revealed
no evidence of gross changes in organs related to the test substance.
The limit test for oral toxicity of TMOA in
rats following single application of the test item revealed the
following median lethal dose (LD50):
male animals > 2000 mg/kg
female animals > 2000 mg/kg
TMOA is of low toxicity based on the LD50 determined. Hence, the
test material was considered to be non-toxic under the conditions of the
test and not requiring classification according to Regulation (EC) No
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