Registration Dossier
Registration Dossier
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EC number: 285-089-6 | CAS number: 85029-63-6
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- other: expert statement
Reference
Description of key information
There are no studies available in which the toxicokinetic properties of the substance were investigated.
The test item, an organic UVCB, which is a pale yellow, viscous liquid at room temprature is readily biodegradable. There is no information on its hydrolytical stability (see IUCLID chapter 5.1.2). The substance forms emulsions in water (critical micelle concentration of the test substance at 25 °C: 0.026 g/L at pH 5.6) and is regarded to be slightly water soluble see IUCLID chapter 4.8). The octanol water partition coefficient (Log Pow) for the substance was calculated to be .4.6 (see IUCLID chapter 4.7).
Absorption
With reference to the slight solubility in water, its complex structure and a Log Pow of 4.6 absorption of the substance is considered to be restricted (please refer to ECHA Guidance on information requirements and chemical assessment, R.7c, Table R.7.12-1, (V3.0; 2017, p. 181). This assumption is especially strengthened by the results of an oral toxicity study in rats (acute oral toxicity study: LD50> 2,000 mg/kg bw) and a Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test (OECD 422): NOAEL 1000 mg/kg bw/d (no adverse changes observed in all dose groups). These data indicate that the substance is not or only to a very low amount bioavailable.
Distribution
Taking into account the slight water solubility of the substance migration into cells is possibly limited. But, due to its Log Pow value intracellular concentration may be higher than extracellular concentration particularly in fatty tissues (please refer to ECHA Guidance on information requirements and chemical assessment, Chapter R.7c, pp. 176-177).
Metabolism
There is no information on the metabolism of the substance. But it can reasonably be assumed that the ester is hydrolysed and that the fatty acids are metabolized by beta-oxidation.
Excretion
There is no information on the excretion of the substance. Degradation products of the fatty acids are possibly used as components in biochemical cycles.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
none
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
