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Diss Factsheets
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EC number: 947-855-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- 1. HYPOTHESIS FOR THE ANALOGUE APPROACH
For environmental toxicity citric acid and ammonium citrate dibasic can be considered to be representative for ammonium dihydrogen citrate. The source chemicals for read across are salts that contain one of the ions and/or citric acid.
2. SOURCE AND TARGET CHEMICAL(S)
SOURCE Chemicals:
* Diammonium citrate, CAS no. 3012-65-5
* Citric acid, CAS no. 77-92-9
TARGET Chemical: Ammonium dihydrogen citrate
3. ANALOGUE APPROACH JUSTIFICATION
Diammonium citrate and the target substance only differ in presence of an ammonium ion, but the main determinant for the partition coefficient is the citrate as the ammonium part is inorganic.
Under the test circumstances of the partition coefficient test (pH=7), for both diammonium citrate and ammonium dihydrogen citrate the citrate is expected to be present in ionized form. Therefore it can be concluded that the partition coefficient will be similar for ammonium citrate dibasic and the target substance and that it is scientifically valid to read-across this value.
4. DATA MATRIX
* Diammonium citrate: Log Pow <0
* Citric acid: Log Pow -0.76 for H2A- and -0.21 for H3A; otherwise log Pow -1.7 or lower - Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Type:
- log Pow
- Partition coefficient:
- < 0
- Remarks on result:
- not measured/tested
- Remarks:
- result based on read-across from 2 sources
- Details on results:
- Considering that the substance is produced in water, and very well soluble in water, the provided analogue data support the theory that the Log Pow of ammonium dihydrogen citrate is <0.
- Conclusions:
- The log Pow of the test item is <0, based on read across from 2 sources.
Reference
Description of key information
The log Pow of the substance is estimated to be <0, based on read-across from data for diammonium citrate (HPLC method at pH 7.7 acc to OECD 117) and data for citric acid (various peer-reviewed data sources).
Read-across is considered justified because the main determinant for the partition coefficient is the citrate ion, as the ammonium part is inorganic. Also, the target substance is well soluble in water, which supports the theory that the Log Pow of ammonium dihydrogen citrate is <0.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.