Registration Dossier
Registration Dossier
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EC number: 204-701-4 | CAS number: 124-43-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
- Reference Type:
- review article or handbook
- Title:
- Wasserstoffperoxid
- Author:
- Deutsche Forschungsgemeinschaft (DFG). Senatskommission zur Prüfung gesundheistschädlicher Arbeitsstoffe
- Year:
- 2 006
- Bibliographic source:
- Wiley Online Library. The MAK Collection for Occupational Health and Safety.
- Report date:
- 2006
- Reference Type:
- review article or handbook
- Title:
- Human Health Tier II assessment for hydrogen peroxide (H2O2)
- Author:
- National Industrial Chemicals Notification and Assessment Scheme (NICNAS). Australian Government. Department of Health.
- Year:
- 2 018
- Bibliographic source:
- https://www.nicnas.gov.au/chemical-information
- Report date:
- 2018
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 951
- Report date:
- 1951
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Determination of acute oral and intravenous toxicity
- GLP compliance:
- no
- Remarks:
- pre-GLP study
- Test type:
- other: dilutions tested, but otherwise not speciified
Test material
- Reference substance name:
- Hydrogen peroxide
- EC Number:
- 231-765-0
- EC Name:
- Hydrogen peroxide
- Cas Number:
- 7722-84-1
- Molecular formula:
- H2O2
- IUPAC Name:
- hydrogen peroxide
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- CAS numer: 7722-84-1
Purity: not stated
Concentration: 90%
Test animals
- Species:
- rabbit
- Strain:
- not specified
Administration / exposure
- Doses:
- not specified
- No. of animals per sex per dose:
- not specified
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Remarks:
- rabbit
- Effect level:
- 700 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Remarks:
- rat
- Effect level:
- 5 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Conclusions:
- The acute oral and dermal toxicity of 90% hydrogen peroxide and dilutions thereof were examined in several species. The rabbit was the most sensitive species with a dermal LD50 of 700 mg/kg bw. The rat was the less sensitive species with a dermal LD50 of 5000 mg/kg bw.
- Executive summary:
The acute oral and dermal toxicity of 90% hydrogen peroxide and dilutions thereof were examined in several species. The rabbit was the most sensitive species with a dermal LD50 of 700 mg/kg bw. The rat was the less sensitive species with a dermal LD50 of 5000 mg/kg bw (Hrubetz et al. 1951).
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