Registration Dossier

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

3-Chloro-o-xylene is hydrolytically stable (OECD 111, 2004).

Additional information

A reliable key study was conducted according to OECD TG 111, hydrolysis screening test (RL1, 2004). The study was conducted in compliance with GLP. The HPLC results indicated that the observed test item concentrations in heated and frozen test solutions were lower than nominal. However, this was not due to the hydrolysis of 3-chloro-o-xylene, because no hydrolysis product was detected. These lower-than-nominal test item concentrations were likely due to the adsorption of 3-chloro-o-xylene to the vial glass, which was supported by results from an additional adsorption experiment. The adsorption experiment examined the effect of varying co-solvent concentrations on the observed test item concentration in pH 9 buffer solutions. In fact, the observed test item concentration generally decreased as the acetonitrile concentration decreased. Therefore, it was concluded that based on the results of the study, 3-chloro-o-xylene was hydrolytically stable (half-life > 1 year at 25 °C). Despite of minor deviation from the test guideline, results of the study were considered reliable and adequate for the environmental hazard assessment.