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Adsorption / desorption

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Reference
Endpoint:
adsorption / desorption: screening
Type of information:
experimental study
Adequacy of study:
key study
Study period:
April 20, 2016 to May 11, 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC estimation method
Media:
sewage sludge
Specific details on test material used for the study:
Name (as stated in the report): Silvial
Batch No.: SC00016538
Expiration date: October 02, 2016
Radiolabelling:
no
Test temperature:
The determination was performed at 35 °C (temperature of the column), but the value obtained can be considered to represent the value at an unspecified, probably ambient temperature since no mention is made in the guidelines of the temperature at which the tabulated reference substances log Koc values were determined. Adsorption coefficients of the test and reference substances are assumed to vary with temperature in the same way.
Details on study design: HPLC method:
HPLC equipment: Perkin Elmer (series 200) HPLC system comprising:
- a high pressure pump (module N2910102, serial number: 291N8051901A)
- an auto-sampler (module N2930100, serial number: 293N8052404A)
- a column compartment (module N2601581, serial number: OVH0802151130)
- a refractive index detector (series 200a, serial number 125829).
- Column: 250 mm x 4.6 mm, Nucleodur 100-5 CN-RP (Macherey-Nagel) serial number: N10080027, batch 34518023
- Mobile phase: methanol / water 55/45 (v/v)
- Flow rate: 1.0 ml/min.
- Column temperature: 35 °C
- Injected volume: 100 µl

Analytical monitoring:
yes
Details on sampling:
A solution of the test substance was prepared (10.0 mg in 25 ml methanol/water 55/45 v/v).
Key result
Sample No.:
#1
Type:
log Koc
Value:
3.2
pH:
7
Temp.:
35 °C
Details on results (HPLC method):
The chromatograms of Silvial show one peak at an average retention times of 5.046 minutes, corresponding to an adsorption coefficient (log value) of 3.2
Validity criteria fulfilled:
yes
Conclusions:
The chromatograms of Silvial show one peak at an average retention times of 5.046 minutes, corresponding to an adsorption coefficient (log value) of 3.2.
Therefore: Adsorption coefficient (KOC) of Silvial: log KOC = 3.2
Executive summary:

The Adsorption coefficient (KOC) on soil and on sewage sludgeof Silvial was determined by the Reverse Phase High Performance Liquid Chromatographic Method according to the OECD Guidelines for Testing of Chemicals, Method No. 121.

The result is: Adsorption coefficient (KOC) of Silvial: Log KOC= 3.2

 

Description of key information

The Adsorption coefficient (KOC) on soil and on sewage sludge of Silvial was determined by the Reverse Phase High Performance Liquid Chromatographic Method according to the OECD Guidelines for Testing of Chemicals, Method No. 121.

The determination was performed at 35°C (column temperature), however the values can be considered to represent the values at an unspecified, probably ambient temperature since no mention is made in the guidelines of the temperature at which the tabulated reference substances log Koc values were determined. Adsorption coefficients of the test and reference substances are assumed to vary with temperature in the same way. The log Koc of Silvial was determined to be 3.2, equivalent to a Koc of 1585.

Key value for chemical safety assessment

Koc at 20 °C:
1 585

Additional information