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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1977
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
abstract
Remarks:
1 page study summary

Data source

Reference
Reference Type:
other: 1 page study summary
Title:
Unnamed
Year:
1977
Report date:
1997

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: no guideline specified on the 1 page study summary
GLP compliance:
no
Remarks:
Conducted prior to the GLP guidelines
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
3-(p-cumenyl)-2-methylpropionaldehyde
EC Number:
229-695-0
EC Name:
3-(p-cumenyl)-2-methylpropionaldehyde
Cas Number:
6658-48-6
Molecular formula:
C14H20O
IUPAC Name:
3-(4-isopropylphenyl)-2-methylpropanal
Specific details on test material used for the study:
Sample marking: 77-413, Rhodial

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Doses:
5'000 mg/Kg BW
No. of animals per sex per dose:
1 dose per animals
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
1 death occurred on day 1

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The LD50 of Silvial in rabbits has been determined to be above 5'000 mg/Kg bw. Hence the GHS criteria are not met for classification.
Executive summary:

The LD50 of Silvial in rabbits has been determined to be above 5'000 mg/Kg bw. Hence the GHS criteria are not met for classification.