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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Link to relevant study record(s)

Description of key information

No OECD 209 study is available for propane-1-thiol therefore reliable measured data are read across from the analogue substance propane-2-thiol. The toxicity of propane-2-thiol to micro-organisms gives a 3 hour EC50 of 880.5 mg/l (Feil, 2010).

Key value for chemical safety assessment

EC50 for microorganisms:
880.5 mg/L
EC10 or NOEC for microorganisms:
1 mg/L

Additional information

Feil (2010) is a GLP-compliant study following OECD guideline 209. The study was conducted in a closed system due the volatile nature of the substance. The minor deviations in substance storage are not considered to have affected the outcome of the experiment. The study is considered reliable and suitable for use for this endpoint.


Both propane-1-thiol and propane-2-thiol have the same molecular weight and are characterised by an SH functional group with an aliphatic carbon chain. The substances vary slightly in having straight and branched aliphatic carbon chains respectively, but the similarities of the physico-chemical, environmental fate and ecotoxicity properties are apparent. Read-across of the microorganism toxicity data is therefore considered to be appropriate.

In addition, the toxicity control of a ready biodegradability study showed that propane-1-thiol is not inhibitory to micro-organisms at a concentration of 1 mg/L. Micro-organisms from a predominantly domestic sewage treatment plant were exposed to 1 mg/L propane-1-thiol for 28 days in dark glass closed biological oxygen demand bottles. The data are taken from Harlan (2012), an unpublished experimental, ready biodegradability study following OECD 301D, which is GLP-compliant. The study is considered to be reliable without restrictions.