Registration Dossier

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1987-09-09
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
No information on GLP compliance

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987
Report date:
1987

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 436 (Acute Inhalation Toxicity: Acute Toxic Class Method)
Deviations:
yes
Remarks:
only one concentration was tested
GLP compliance:
not specified
Test type:
acute toxic class method

Test material

Constituent 1
Chemical structure
Reference substance name:
Propane-1-thiol
EC Number:
203-455-5
EC Name:
Propane-1-thiol
Cas Number:
107-03-9
Molecular formula:
C3H8S
IUPAC Name:
propane-1-thiol
Details on test material:
- Name of test material (as cited in study report): propane-1-thiol

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Charles River UK Ltd., Margate, Kent
- Age at study initiation: 6 to 8 weeks
- Housing: polypropylene cages that had detachable wire mesh tops and floors and were suspended on a movable rack
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 5 days

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
No data reported
Duration of exposure:
>= 4
Concentrations:
5.663 mg/L
No. of animals per sex per dose:
5 per sex per dose
Control animals:
yes
Details on study design:
- Duration of observation period following administration: 14 days

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 5.663 mg/L air
Mortality:
There were no deaths following exposure to propane-1-thiol vapour at a concentration of 5.663 mg/L
Clinical signs:
other: During exposure Signs of irritant effects including partial closing of the eyes, reduced respiration rate, abnormal respiration movements and adoption of a hunched body posture During the observation period Increased respiratory rate immediately followin
Body weight:
Food and water consumption was reduced among exposed males and females for 1 day. Weight gain by rats exposed to propane-1-thiol was reduced for 1 day (males) or up to 4 days (females) post exposure. No further data were presented.
Other findings:
Lung weight to bodyweight ratios were within normal limits for all rats with the possible exception of one that was exposed to propane-1-thiol vapour. No treatment-related findings were observed at gross necropsy (no further details presented in report).

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
This study reported no toxic effects in rabbits exposed via inhalation to propane-1-thiol.
Executive summary:

In an acute inhalation toxicity study, groups of young adult albino Sprague-Dawley rats (5/sex) were exposed by inhalation route to propane-1-thiol for 4 hours to whole body at a concentration of 5.663 mg/L. Animals then were observed for 14 days.

 

There were no deaths following exposure to propane-1-thiol vapour at a concentration of 5.663 mg/l. During exposure there were signs of irritant effects including partial closing of the eyes, reduced respiration rate, abnormal respiration movements and adoption of a hunched body posture. Rats showed increased respiratory rate immediately following exposure, which subsequently returned to normal. Weight gain by rats exposed to propane-1-thiol was reduced for 1 day for males or up to 4 days for females post exposure. The inhalation LC50 was determined to be greater than 5.663 mg/l in males and females.

 

This study received a Klimisch score of 2 and is classified as reliable with restrictions because, although only summary results were presented, there was good data on test conditions and substance but no mention of GLP compliance.

Categories Display