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Melting point / freezing point

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Description of key information

The melting point was determined in a study to characterize different production batches of testosterone with respect to their solid state form.

General Physical Chemistry, Schering AG Berlin. Study report No. N412 (APC 70/98), dated 2002-03-25.

Result: 155°C (428 K), Polymorph I

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
155 °C

Additional information

Testosterone is a solid under ambient conditions. According to the literature at least four anhydrates, named polymorphs I, II, III and IV, as well as two monohydrate forms, called monohydrates I and II, are existing. Polymorph I crystallizes from the most solvents under exclusion of moisture. This polymorph melts at about 155°C. Polymorphs II, III and IV are obtained from melt. Melting temperatures of 148°C (polymorph II), 144°C (polymorph III) and 143°C (polymorph IV) are given. Crystallisation from water/solvent mixtures, the influence of air moisture on the crystallisation process and the treatment with water give monohydrates I, II or mixture of both. The dehydration of both monohydrates yielded polymorph I.

The working standard batch as well as five production batches, crystallized according to the manufacturing formula, consist of polymorph I. The melting point of 155°C was confirmed by DSC/TG measurements using a Setaram Labsys TM TG-DSC (at a heating rate of 5 K/min in in open crucibles under a helium atmosphere (onset temperature 153.9°C (427.1 K) ± 0.7 K).