Registration Dossier

Ecotoxicological information

Short-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to fish
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
Read-across (analogue): For justification of read-across see section 13.2.
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across: supporting information
Reason / purpose for cross-reference:
read-across: supporting information
Reason / purpose for cross-reference:
read-across: supporting information
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
>= 21 - <= 217 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Conclusions:
Based on read across studies for short term toxicity to fish on chemically similar substances the LC50(fish, 96h) for the target substance Fatty acids, C14-18 and C16-18-unsatd., ammonium salts is estimated to be >=21 mg/l (to <= 217mg/l).

Description of key information

Based on read across studies for short term toxicity to fish on chemically similar substances the LC50(fish, 96h) for the target substance Fatty acids, C14 -18 and C16 -18 -unsatd., ammonium salts is estimated to be >=21 mg/l  (to <= 217mg/l).

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
21 mg/L

Additional information

Several publication are available in which the acute toxicity to fish of the analogue substances (Sodium oleate, Sodium myristate, Sodium palmitate, Sodium stearate) were determined. Therefore,

after acclimatization red killifish (Oryzias latipes) were exposed to several concentrations of the read across substance. The test followed a semi-static procedure with an exposure time of 96 h. As results, the following LC50 values in freshwater were determined: 217 mg/L for sodium oleate, 118 mg/L for sodium myristate, 150 mg/L for sodium palmitate and 125mg/L for sodium stearate.

Additionally, an acute aquatic toxicity test was conducted on fish to assess the LC50 (96 h) of sodium myristate. The study was conducted in 2000 according to OECD guideline 203 and in compliance with GLP by the MOE (Ministry of the Environment in Japan). As a result, an LC50 of >21 mg/L was revealed.

Based on the structural similarity of the target substance to the analogue substances the results of the acute toxicity to fish of the source substances can be assigned to the target substance.

The supporting information of the short term toxicity to fish of the analogue substances: sodium oleate (LC50(fish, 96h): >100mg/l), sodium stearate (LC50(fish, 96h): >100mg/l) and sodium laurate (LC50(Oryzias latipes, 96h): 11mg/l) are stated below. But these information are less appropriate for the read-across projection to short term toxicity to fish of the target substance (laurate is only an impurity).