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EC number: 947-954-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
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- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: Department of Transportation, Method of Testing Corrosion to Skin
- Version / remarks:
- Federal Register, Vol 41, No 118, Sept 27 1976
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1992
- Deviations:
- no
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Phosphoric acid, mono(C8-12 (even-numbered) linear alkyl) ester
- Molecular formula:
- Not applicable (UVCB)
- IUPAC Name:
- Phosphoric acid, mono(C8-12 (even-numbered) linear alkyl) ester
- Reference substance name:
- Phosphoric acid, di(C8-12 (even-numbered) linear alkyl) ester
- Molecular formula:
- Not applicable (UVCB)
- IUPAC Name:
- Phosphoric acid, di(C8-12 (even-numbered) linear alkyl) ester
- Test material form:
- liquid
- Details on test material:
- Phosphoric acid, C8-12 (even-numbered) - linear alkyl) esters (1.5 ester groups per molecule)
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Remarks:
- albino
- Details on test animals or test system and environmental conditions:
- ANIMALS AND ANIMAL HUSBANDRY
- Rabbits were sourced from Kuiper Rabbitry, Gary, Indiana, USA and were approximately 8-10 weeks old.
- Animals were housed individually in stainless steel cages in a temperature, humidity and light controlled room.
- Rabbits were conditioned for at least three days prior to study initiation.
- Purina Rabbit Chow and water were available ad libitum.
- All animals used for the investigation were considered to be in good health at study initiation.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 3 minutes, 1 hour and 4 hours
- Observation period:
- 7 days
- Number of animals:
- Six
- Details on study design:
- COMPOUND ADMINISTRATION
- Three intact sites were prepared on each of the six animals.
- A dose of 0.5 mL of the test article was applied to the occluded sites for contact periods of 3 minutes (site A), 1 hour (site B) and 4 hours (site C).
- At the conclusion of the individual contact periods, any remaining test material was wiped from the site.
- If necrosis was observed at the shorter contact periods the test was considered to be concluded and longer exposure times were not required.
CLINICAL OBSERVATIONS
- Observations for irritation, ulceration and necrosis were performed at the end of each contact period.
- Observations were repeated at 60 minutes for the 3 minute contact time.
- Observations were repeated at 24, 48 and 72 hours following test article application for the 1 and 4-hour contact times.
- Additional readings were continued up to Day 7 to confirm transport packing group
- Corrosion was considered to have resulted if the substance in contact with rabbit skin produced full thickness destruction or irreversible alteration of tissue.
- Tissue destruction was considered to have occurred if ulceration and/or necrosis was observed at any of the readings.
- Tissue destruction did not include merely sloughing of the epidermis, erythema, edema or fissuring.
- Scoring crieria used during evaluation of skin reactions are given in Table 2 (attached).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 3 min contact time
- Time point:
- other: 3 min
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks:
- site A
- Remarks on result:
- other:
- Remarks:
- Animals 53, 54, 55, 56, 57 and 58
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 3 min contact time
- Time point:
- other: 1 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks:
- site A
- Remarks on result:
- other: not corrosive after 3 min contact time
- Remarks:
- Animals 53, 54, 55, 56, 57 and 58
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- 1 h contact time
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- site B
- Remarks on result:
- other: Animal 53
- Remarks:
- Necrosis reported at 7 d observation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- 1 h contact time
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- site B
- Remarks on result:
- other: Animal 54
- Remarks:
- Score unchanged at 7 d observation
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Remarks:
- 1 h contact time
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- site B
- Remarks on result:
- other: Animal 55
- Remarks:
- Necrosis reported at 72 h observation
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Remarks:
- 1 h contact time
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- site B
- Remarks on result:
- other: Animal 56
- Remarks:
- Score unchanged at 7 d observation
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Remarks:
- 1 h contact time
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- site B
- Remarks on result:
- other: Animal 57
- Remarks:
- Score unchanged at 7d observation
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Remarks:
- 1 h contact time
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Animal 58
- Remarks:
- Necrosis reported at 7 d observation
- Irritant / corrosive response data:
- - Data showing individual responses of each animal are attached.
- Occluded contact with the test material for three minutes produced no irritation and necrosis was not observed in any of the six animals.
- Occluded contact with the test material for one hour produced severe irritation and necrosis was observed in three of the six animals within 7 days.
- Occluded contact with the test material for four hours caused necrosis in all six animals.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Conclusions:
- Occluded contact with the test item for one hour produced severe irritation (erythema scores at 24/48/72 hours ≥ 2.3 in 5/6 animals) and necrosis was observed in three of the six animals within 7 days. On the basis of this study, the test material is found to be corrosive to skin.
- Executive summary:
In a study performed in accordance with US D.O.T. regulations and OECD 404, the test item was applied to three prepared skin sites on New Zealand White rabbits under occluded conditions for 3 minutes, 1 hour and 4 hours. After the relevant contact period, any remaining test item was wiped from the site. After removal of patches and 24, 48 and 72 hours later, the test sites were examined for evidence of primary irritation and scored for erythema. No effects were noted over a period of 60 minutes following contact with the test item for 3 minutes. However, occluded contact with the test item for one hour produced severe irritation (erythema scores at 24/48/72 hours ≥ 2.3 in 5/6 animals) and necrosis was observed in three of the six animals within 7 days. On the basis of this study, the test material is found to be corrosive to skin.
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