Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Effects on fertility

Effect on fertility: via oral route
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
NOAEL
10 mg/kg bw/day
Study duration:
chronic
Species:
rat

Effects on developmental toxicity

Effect on developmental toxicity: via oral route
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
NOAEL
11.12 mg/kg bw/day
Study duration:
chronic
Species:
rat
Additional information

The NOAEL value is stated as Fluoride and not as zinc hexafluorosilicate.

Justification for classification or non-classification

The available information from repeated dose toxicity studies as well as reproductive toxicity studies do not indicate a hazard for female reproduction in relation to exposure to fluoride. A recent two-generation study focussing on the damage to the male reproductive system, no testicular effects were seen at an exposure level of 250 mg NaF/L. Additionally, it is especially noted that in none of the animal carcinogenicity studies effects on morphology ofany of the reproductive organs were found.

Additional information