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Bioaccumulation: aquatic / sediment

BCFBAF model of Estimation Programs Interface (2018) was used to predict the bioconcentration factor (BCF) of test chemical 1,3-Benzenediamine, coupled with diazotized m-phenylenediamine, acetates (CAS No. 84281 -74 -3). The bioconcentration factor (BCF) of 1,3-Benzenediamine, coupled with diazotized m-phenylenediamine, acetates was estimated to be 56.23 L/kg whole body w.w (at 25 deg C) which does not exceed the bio concentration threshold of 2000, indicating that the chemical 1,3-Benzenediamine, coupled with diazotized m-phenylenediamine, acetates is not expected to bioaccumulate in the food chain.

Additional information

Bioaccumulation: aquatic / sediment

Various predicted data for the target compound 1,3-Benzenediamine, coupled with diazotized m-phenylenediamine, acetates(CAS No. 84281-74-3) and supporting weight of evidence studies for its structurally and functionally similar read across substance were reviewed for the bioaccumulation end point which are summarized as below:

 

In a prediction done using the BCFBAF Program of Estimation Programs Interface (2018) was used to predict the bioconcentration factor (BCF) of test chemical 1,3-Benzenediamine, coupled with diazotized m-phenylenediamine, acetates (CAS No. 84281 -74 -3). The bioconcentration factor (BCF) of 1,3-Benzenediamine, coupled with diazotized m-phenylenediamine, acetates was estimated to be 56.23 L/kg whole body w.w (at 25 deg C).

 

In a supporting weight of evidence study from authoritative databases (J-CHECK and EnviChem, 2018) for the test item,bioaccumulation experiment was conducted on test organism Cyprinus carpio for 6 weeks for evaluating the bioconcentration factor (BCF value) of test chemical. The study was performed according to other guideline "Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances", respectively. Cyprinus carpio was used as a test organism for the study. Test chemical was prepared inHCO-40.Test chemical nominal conc. used for the study was 0.35 mg/land 0.035 mg/l, respectively. Analytical method involve the recovery ratio: Test water: 98.3 %, Fish : 96.7 %, - Limit of quantitation : Test water :1st concentration area : 100 %, 2nd concentration area : 98.6 %, Fish : 90.8 %, - Limit of detection : Fish : 0.103 ppm. Range finding study involve the TLm(48h) ≥ 100 ppm (w/v) on Rice fish (Oryzias latipes).The bioconcentration factor (BCF value) of test substance on Cyprinus carpio was determined to be in the range of 0.29-2.9 L/Kg at a conc. of 0.35 mg/l and 2.9-11 L/Kg at a conc. of 0.035 mg/l, respectively.

 

For the test chemical,bioaccumulation study was conducted on test organism Cyprinus carpio for 6 weeks for evaluating the bioconcentration factor (BCF value) of test chemical (J-CHECK and EnviChem, 2018). The study was performed according to other guideline "Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances", respectively. Cyprinus carpio was used as a test organism for the study. Test chemical was prepared inHCO-40.Test chemical nominal conc. used for the study was 0.1mg/land 0.01 mg/l, respectively. Analytical method involve therecovery ratio: Test water: 98.3 %, Fish : 96.7 %, - Limit of quantitation : Test water :1st concentration area : 94.2 %, 2nd concentration area : 100 %, Fish : 80.7 %, - Limit of detection : Fish : 0.0186 ppm. Range finding study involve the TLm(48h) ≥ 420 ppm (w/v)on Rice fish (Oryzias latipes).The bioconcentration factor (BCF value) of test substance on Cyprinus carpio was determined to be in the range of 0.38-3.2 L/Kg at a conc. of 0.1 mg/l and 2.4-5.4 L/Kg at a conc. of 0.01 mg/l, respectively.

 

On the basis of above results for target chemical 1,3-Benzenediamine, coupled with diazotized m-phenylenediamine, acetates (from modelling databases, 2018), it can be concluded that the BCF value of test substance1,3-Benzenediamine, coupled with diazotized m-phenylenediamine, acetates was estimated to be 56.23 L/kg which does not exceed the bioconcentration threshold of 2000, indicating that the chemical1,3-Benzenediamine, coupled with diazotized m-phenylenediamine, acetates is not expected to bioaccumulate in the food chain.

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