Reaction mass of calcium 2,6-bis(3-carboxylatopropanamido)hexanoate and isomers of calcium amino-(3-carboxylatopropanamido)hexanoate

Repeated dose toxicity: dermal

Administrative data

Endpoint:

chronic toxicity: dermal

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Justification for type of information:

Testing for repeated dermal toxicity is not necessary since (i) skin contact in production and/or use is unlikely and (ii) the physicochemical and toxicological properties suggest no potential for a significant rate of absorption through the skin. Additional testing by dermal route is not applicable as a repeated dose screeing reproductive/developmental toxicity study via the oral route was performed.