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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2018-06-12 to 2018-07-30
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
yes
Remarks:
The preliminary test, miscibility test with visual inspection was performed.
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
yes
Remarks:
The preliminary test, miscibility test with visual inspection was performed.
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Deviations:
yes
Remarks:
The preliminary test, miscibility test with visual inspection was performed.
GLP compliance:
yes (incl. QA statement)
Type of method:
other: miscible test with visual inspection
Key result
Remarks on result:
completely miscible

No precipitations were observed by visual inspection in any of the prepared solutions. Hence, it is considered that the test item is completely miscible with milli-Q water at room temperature.

Table 1. Miscibility test

Ratios

Ratios Volume

Visual Observation

Test item : Milli Q water (1: 9)

10 mL : 90 mL

Miscible

Test item : Milli Q water (1: 1)

50 mL : 50 mL

Miscible

Test item : Milli Q water (9: 1)

90 mL : 10 mL

Miscible

 

Conclusions:
The test item is completely miscible in water at room temperature.
Executive summary:

A study according to OECD TG 105, EU Method A.6 and OPPTS 830.7840 was conducted to determine the water solubility of the test item. The test item was expected to be miscible in water, therefore, a preliminary test with visual inspection was performed. Three ratios test item : water were prepared – 1:9, 1:1 and 9:1. After preparation of the test solutions it was visually determined if precipitation was formed. No precipitation was observed in any of the tested ratios. In conclusion, the test item is considered to be completely miscible in water at room temperature.

Description of key information

The test item is completely miscible in water at room temperature.

Key value for chemical safety assessment

Additional information

A study according to OECD TG 105, EU Method A.6 and OPPTS 830.7840 was conducted to determine the water solubility of the test item. The test item was expected to be miscible in water, therefore, a preliminary test with visual inspection was performed. Three ratios test item : water were prepared – 1:9, 1:1 and 9:1. After preparation of the test solutions it was visually determined if precipitation was formed. No precipitation was observed in any of the tested ratios. In conclusion, the test item is considered to be completely miscible in water at room temperature.

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