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EC number: 263-193-2
CAS number: 61791-59-1
Readily biodegradable (85.2% in 28 d, OECD 301 B); read-across
There is no experimental study available, in which the ready
biodegradability of the target substance Glycine, N-methyl-, N-coco acyl
derivatives, sodium salts (CAS 61791-59-1) was assessed. Therefore, in
accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5, read-across
to three studies with the two structurally and chemically closely
and N-methyl-N-(1-oxotetradecyl)aminoacetate (CAS 30364-51-3) was
performed in order to fulfill the standard data requirements for the
target substance. A detailed read-across approach justification is
provided in IUCLID section 13.
One GLP guideline study is available for the source
substanceN-methyl-N-[C18-(unsaturated)alkanoyl]glycine (EC 701-177-3).
In this study according to OECD guideline 301 B (Laus, 2005), 20
mg/L test item (based on TOC) was inoculated with 25 mg/L activated
sludge for 28 d. An Inoculum blank, an abiotic sterile control and a
toxicity control were run in parallel. CO2 was trapped in bottles
containing 0.25 M NaOH solution and the evolution of CO2 concentration
was followed by TOC analysis in regular intervals.
After 28 d incubation, the test item was degraded by 85.2% in
terms of CO2 evolution. Thus, it can be concluded that
N-methyl-N-(C18-(unsaturated)alkanoyl)glycine (EC 701-177-3) is readily
biodegradable according to the OECD guideline criteria.
Two GLP guideline studies with the source substance sodium
N-methyl-N-(1-oxotetradecyl)aminoacetate (CAS 30364-51-3) are available,
which were performed according to OECD guideline 301 B and 310,
In the study according to OECD 301 B (Chemex, 2013) 104.95 mg/L
test item was inoculated with activated sludge. After 28 d, a mean
degradation of 83 % was observed but the 10-day window was not met by
one day (60% on Day 14 instead of Day 13). In the study according to
OECD 310 (Hydrotox, 2005) a test item concentration of 20 mg/L based on
total inorganic carbon (TIC) was inoculated with activated sludge. After
28 d, a mean biodegradation of 71% was reported but the 10-day window
was not met by just one day (60% biodegradation obtained on Day 13,
instead of Day 12).
Based on the structural and chemical similarity of the target and
source substances, the target substance is expected to exhibit a similar
environmental fate profile as the selected source substances. Therefore,
it can be concluded that the target substance Glycine, N-methyl-, N-coco
acyl derivatives, sodium salts (CAS 61791-59-1) is readily biodegradable
according to OECD guideline criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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