Glycine, N-methyl-, N-coco acyl derivs., sodium salts

Biodegradation in water: screening tests

Link to relevant study record(s)

Reference

Endpoint:

biodegradation in water: ready biodegradability

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Remarks:

Summary of available data used for the endpoint assessment of the target substance.

Adequacy of study:

key study

Justification for type of information:

Refer to the analogue approach justification provided in IUCLID section 13.

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Parameter:

% degradation (CO2 evolution)

Value:

85.2

Sampling time:

28 d

Remarks on result:

other:

Remarks:

Source: RA-A, EC 701-177-3, Hydrotox, 2005, OECD 301 B

Parameter:

% degradation (CO2 evolution)

Value:

71

Sampling time:

28 d

Remarks on result:

other:

Remarks:

Source: RA-A, CAS 30364-51-3, Hydrotox, 2005, OECD 310

Parameter:

% degradation (CO2 evolution)

Value:

83

Sampling time:

28 d

Remarks on result:

other:

Remarks:

Source: RA-A, CAS 30364-51-3, Chemex, 2013, OECD 301B

Conclusions:

The target substance is readily biodegradable according to available experimental data from three studies for two structurally and chemically closely related source substances (OECD 301 B and OECD 310); read-across

Description of key information

Readily biodegradable (85.2% in 28 d, OECD 301 B); read-across

Additional information

There is no experimental study available, in which the ready biodegradability of the target substance Glycine, N-methyl-, N-coco acyl derivatives, sodium salts (CAS 61791-59-1) was assessed. Therefore, in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5, read-across to three studies with the two structurally and chemically closely related source substancesN-methyl-N-[C18-(unsaturated)alkanoyl]glycine(EC 701-177-3) and N-methyl-N-(1-oxotetradecyl)aminoacetate (CAS 30364-51-3) was performed in order to fulfill the standard data requirements for the target substance. A detailed read-across approach justification is provided in IUCLID section 13.

One GLP guideline study is available for the source substanceN-methyl-N-[C18-(unsaturated)alkanoyl]glycine (EC 701-177-3).

In this study according to OECD guideline 301 B (Laus, 2005), 20 mg/L test item (based on TOC) was inoculated with 25 mg/L activated sludge for 28 d. An Inoculum blank, an abiotic sterile control and a toxicity control were run in parallel. CO2 was trapped in bottles containing 0.25 M NaOH solution and the evolution of CO2 concentration was followed by TOC analysis in regular intervals.

After 28 d incubation, the test item was degraded by 85.2% in terms of CO2 evolution. Thus, it can be concluded that N-methyl-N-(C18-(unsaturated)alkanoyl)glycine (EC 701-177-3) is readily biodegradable according to the OECD guideline criteria.

Two GLP guideline studies with the source substance sodium N-methyl-N-(1-oxotetradecyl)aminoacetate (CAS 30364-51-3) are available, which were performed according to OECD guideline 301 B and 310, respectively.

In the study according to OECD 301 B (Chemex, 2013) 104.95 mg/L test item was inoculated with activated sludge. After 28 d, a mean degradation of 83 % was observed but the 10-day window was not met by one day (60% on Day 14 instead of Day 13). In the study according to OECD 310 (Hydrotox, 2005) a test item concentration of 20 mg/L based on total inorganic carbon (TIC) was inoculated with activated sludge. After 28 d, a mean biodegradation of 71% was reported but the 10-day window was not met by just one day (60% biodegradation obtained on Day 13, instead of Day 12).

 

Based on the structural and chemical similarity of the target and source substances, the target substance is expected to exhibit a similar environmental fate profile as the selected source substances. Therefore, it can be concluded that the target substance Glycine, N-methyl-, N-coco acyl derivatives, sodium salts (CAS 61791-59-1) is readily biodegradable according to OECD guideline criteria.