Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Additional information

The target substance Glycine, N-methyl-, N-coco acyl derivatives, sodium salts (CAS 61791-59-1) has a low potential for bioaccumulation at environmentally relevant pH based on its physico-chemical properties, including a log Kow of -1.3 (23 °C, OECD 117) and a log D (used for ionisable substances instead of log Kow) of 0.61 to 2.40 at pH 7 and of -0.30 to 1.53 at pH 9 (SPARC v4.6). According to REACh regulation (EC) No 1907/2006, substances with log Kow ≤ 3.0 have a low potential for bioaccumulation. Thus, further testing is not required in accordance with Annex IX, column 2, 9.3.2. of Regulation (EC) No. 1907/2006.

Furthermore, predicted BCF values also indicate that the potential for bioconcentration in aquatic organisms is low. The estimated BCF values are 3.16 L/kg wet-wt (BCFBAF model v3.01 regression-based), 0.89 L/kg wet-wt (BCFBAF model v3.01 Arnot-Gobas, including biotransformation upper trophic) and 3.0 – 74.0 L/kg wet-wt (VEGA v1.2.3, CAESAR, Meylan and KNN models), which are clearly below the cut-off values of 2000 L/kg wet-wt for bioaccumulative and 5000 L/kg wet-wt for very bioaccumulative substances, as laid down by section 1 of Annex XIII of REACH Regulation (EC) No 1907/2006. In addition, toxicokinetic considerations with regard to absorption, distribution, metabolisation and excretion of the substance provide further evidence for a low potential for bioaccumulation.

In conclusion, the potential for bioaccumulation is expected to be low for Glycine, N-methyl-, N-coco acyl derivatives, sodium salts (CAS 61791-59-1).