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Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Reference
Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Remarks:
Summary of available data used for the endpoint assessment of the target substance.
Adequacy of study:
key study
Justification for type of information:
Refer to the analogue approach justification provided in IUCLID section 13.
Reason / purpose for cross-reference:
read-across source
Duration:
72 h
Dose descriptor:
EC10
Effect conc.:
4.448 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Remarks on result:
other:
Remarks:
source, RA-A, CAS 30364-51-3, Chemex, ENV11320/ECO161127, 2017, P. subcapitata, 72 h, RL1
Duration:
72 h
Dose descriptor:
EC50
Effect conc.:
13.47 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Remarks on result:
other:
Remarks:
Key, source, RA-A, CAS 30364-51-3, Chemex, ENV11320/ECO161127, 2017, P. subcapitata, 72 h, RL1
Duration:
72 h
Dose descriptor:
NOEC
Effect conc.:
3.2 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Remarks on result:
other:
Remarks:
Key, source, RA-A, CAS 30364-51-3, Chemex, ENV11320/ECO161127, 2017, P. subcapitata, 72 h, RL1
Conclusions:
After 72 h inhibition of growth was observed in the two highest test concentrations (10 and 32 mg/L) resulting in an ErC50 (72 h) of 13.47 mg/L (nominal) and an ErC10 (72 h) of 4.448 mg/L (nominal).

Description of key information

ErC50 (72 h) = 13.47 mg/L (nominal, OECD 201, P. subcapitata); read-across

ErC10 (72 h) = 4.448 mg/L (nominal, OECD 201, P. subcapitata); read-across

Key value for chemical safety assessment

EC50 for freshwater algae:
13.47 mg/L
EC10 or NOEC for freshwater algae:
4.448 mg/L

Additional information

No studies investigating the toxicity to algae are available for Glycine, N-methyl-, N-coco acyl derivatives, sodium salts (CAS 61791-59-1). Therefore, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substance Sodium N-methyl-N-(1-oxotetradecyl)aminoacetate (CAS 30364-51-3) was conducted. Based on the high degree of similarity between the structural and physico-chemical properties of the target and source substance, the source substance is considered suitable representatives for the evaluation of the toxicity to algae of the target substance. The read-across approach is justified in detail within the analogue justification in IUCLID section 13.

The GLP-study with the source substance Sodium N-methyl-N-(1-oxotetradecyl)aminoacetate (CAS 30364-51-3) was conducted according to the OECD guideline 201. The first main test did not meet the validity criteria as the coefficient of variation of the replicates for the control was > 7% for the 72-hour test period. Therefore, this main test was repeated. All validity criteria for the second main test were met. The freshwater algae Pseudokirchneriella subcapitata was exposed for 72 h to nominal test concentrations of 0.32, 1.0, 3.2, 10.0, and 32.0 mg/L. No analytical measurement was conducted. After 72 h inhibition of growth was observed in the two highest test concentrations (10 and 32 mg/L) resulting in an ErC50 (72 h) of 13.47 mg/L (nominal) and an ErC10 (72 h) of 4.448 mg/L (nominal).

Based on the available results from one structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a comparable structure, it can be concluded that Glycine, N-methyl-, N-coco acyl derivatives (CAS 68411-97-2) will exhibit comparable effects on aquatic algae.