Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 263-058-8 | CAS number: 61789-40-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from secondary source
Data source
Reference
- Reference Type:
- other: Secondary source
- Title:
- Acute dermal toxicity of test chemical
- Author:
- U. S. Environmental Protection Agency (EPA)
- Year:
- 2 001
- Bibliographic source:
- U. S. Environmental Protection Agency (EPA), 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- To determine the acute dermal toxicity of test chemical in rabbits.
- GLP compliance:
- not specified
- Test type:
- other: Acute dermal toxicity
- Limit test:
- yes
Test material
- Reference substance name:
- Amides, coco, N-(hydroxyethyl)
- EC Number:
- 268-770-2
- EC Name:
- Amides, coco, N-(hydroxyethyl)
- Cas Number:
- 68140-00-1
- Molecular formula:
- CH3(CH2)nCONHCH2CH2OH
- IUPAC Name:
- Amides, coco, N-(hydroxyethyl)
- Details on test material:
- IUPAC name: Amides, coco, N-(hydroxyethyl)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Weight at study initiation: 1.9 - 2.7 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Trunk
- % coverage: Not specified
- Type of wrap if used: plasticized material
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): Not specified
- Concentration (if solution): Not specified
- Constant volume or concentration used: yes/noNot specified
- For solids, paste formed: yes/noNot specified - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- Three male and three female rabbits
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Not specified
- Necropsy of survivors performed: no
- Clinical signs including body weight : yes, observed
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: skin response and general behavior - Statistics:
- Not specified
Results and discussion
- Preliminary study:
- Not specified
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- All animals survived.
- Clinical signs:
- other: All animals appeared normal through day 14.
- Gross pathology:
- Not specified
- Other findings:
- Not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- Acute dermal toxicity study was performed on rabbits. The LD50 was determined to be > 2000 mg/kg bw indicating that the test chemical is not toxic in nature.
- Executive summary:
An acute dermal toxicity study was performed on rabbits to determine the toxic nature of the test chemical. Three male and three female Albino Rabbits weighing 1.9 -2.7 kg were dosed at a single concentration of 2000 mg/kg bw. Prior to dosing the trunk of each animal was clipped free of hair. Three of the animals (two male, one female) were further prepared by introducing epidermal abrasions over the clipped skin surface to enhance penetrability of the test substance through the stratum corneum. After test substance application the trunk of each animal was encased in a sleeve of plasticized material for 24 hours. Following the 24-hour exposure period the sleeve was removed and the skin sites gently cleansed. All animals were observed daily thereafter for 14 days for mortality, skin response and general behavior. No mortality was observed, and all animals appeared normal during the 14 days observation period. Two females that had abraded skin lost weight (0.01 and 0.25 kg) over the 14-day post-exposure period. All remaining rabbits gained weight through day 14. Thus, the LD50 was observed to be >2000 mg/kg bw indicating that the test chemical is not toxic in nature and falls under category 'Not classified'.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.