Registration Dossier
Registration Dossier
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EC number: 203-203-4 | CAS number: 104-45-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion, other
- Remarks:
- Human volunteer study
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 05 June 1974
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test:
Skin irritation study in human volunteers as a 'pre-test' for a skin sensitization study.
- Short description of test conditions: Five subjects were exposed to the test item for 48 hours.
- Parameters analysed / observed: No details reported. - GLP compliance:
- no
Test material
- Reference substance name:
- p-propylanisole
- EC Number:
- 203-203-4
- EC Name:
- p-propylanisole
- Cas Number:
- 104-45-0
- Molecular formula:
- C10H14O
- IUPAC Name:
- 1-methoxy-4-propylbenzene
Constituent 1
- Specific details on test material used for the study:
- No details reported.
Test animals
- Species:
- other: Human volunteers
- Strain:
- other: Not applicable
- Details on test animals or test system and environmental conditions:
- No details on the test subjects were reported.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- no
- Amount / concentration applied:
- No details reported.
- Duration of treatment / exposure:
- 48 hours
- Observation period:
- No details reported.
- Number of animals:
- Five healthy adult volunteers.
- Details on study design:
- No details reported.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Not specified
- Basis:
- other: Not specified
- Time point:
- other: Not specified
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No subject had any irritation from the test item. No further details reported.
- Other effects:
- No further details reported.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- A patch of the test item was applied to the normal sites on the backs of five human volunteers for 48 hours under occlusion. No subject had any irritation from the test item.
- Executive summary:
A patch of the test item was applied to the normal sites on the backs of five human volunteers for 48 hours under occlusion. No subject had any irritation from the test item.
The test substance was not considered to be irritating under test conditions, according to CLP criteria (EC Regulation 1272/2008).
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