4-methylbenzyl alcohol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1978

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1978

Report date:

1978

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

4-methylbenzyl alcohol

EC Number:

209-639-1

EC Name:

4-methylbenzyl alcohol

Cas Number:

589-18-4

Molecular formula:

C8H10O

IUPAC Name:

(4-methylphenyl)methanol

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
no details available

ENVIRONMENTAL CONDITIONS
no details available

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

not specified

Details on oral exposure:

no details available

Doses:

1220, 2470, 5000, 10140 mg/kg bw

No. of animals per sex per dose:

10 animals / dose

Control animals:

other: not required

Details on study design:

no details available

Results and discussion

Preliminary study:

no details available

Effect levels

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

3 900 mg/kg bw

Based on:

test mat.

95% CL:

> 2 700 - < 5 500

Mortality:

1220 mg/kg bw: 0/10
2470 mg/kg bw: 1/10
5000 mg/kg bw: 8/10
10140 mg/kg bw: 10/10

Clinical signs:

other: 1220 mg/kg bw: Chromorhinorrhea, piloerection, lethargy 2470 mg/kg bw: Diarrhea, chromorhinorrhea, piloerection, lethargy, prostration, ataxia, ptosis, chromodacryorrhea, tachypnea, tremors, right eye crust shut 5000 mg/kg bw: Piloerection, lethargy, ptos

Gross pathology:

see table below

Any other information on results incl. tables

Necropsy observations:

Doses mg/kg	1220	2470	5000	10140
Normal	8	9	1
Cannibalized		1
Exudate, nose/mouth, yellow			2	3
Intestines, areas red			7	8
Intestines, areas yellow			5	10
Intestines, bloated				1
Stomach, areas red			9
Liver dark			7	7
Liver mottled			1
Lungs dark			5	5
Lungs areas dark			2	4
Kidney dark				6
Kidney mottled	1		1
Kidney pale			1
Spleen large	1

Applicant's summary and conclusion

Conclusions:

In an acute oral toxicity study the LD50 was determined to be 3900 mg/kg bw.

Executive summary:

In a study performed 1978, the acute oral toxicity of the test item was determined. The study was conducted with 10 rats per group. The test item was administered in doses of 1220, 2470, 5000 and 10140 mg/kg bw. The animals were observed for mortality and/or systemic effects. Mortality was observed in doses from 2470 mg/kg bw onwards. The LD50 was determined to be 3900 mg/kg bw.