Registration Dossier

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
secondary source
Title:
IUCLID dataset for 38861-78-8
Author:
European Commission - European Chemicals Bureau
Year:
2000
Report date:
2000

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Version / remarks:
1981
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1-[4-(2-methylpropyl)phenyl]ethan-1-one
EC Number:
254-159-8
EC Name:
1-[4-(2-methylpropyl)phenyl]ethan-1-one
Cas Number:
38861-78-8
Molecular formula:
C12H16O
IUPAC Name:
1-[4-(2-methylpropyl)phenyl]ethan-1-one

Test animals

Species:
rabbit

Test system

Type of coverage:
semiocclusive
Preparation of test site:
other: intact
Vehicle:
not specified
Amount / concentration applied:
A single dose of 0.5 ml were given
Duration of treatment / exposure:
One application for four hours
Observation period:
Seven days
Number of animals:
6

Results and discussion

In vivo

Results
Irritation parameter:
other: not specified
Basis:
mean
Time point:
7 d
Reversibility:
fully reversible within: 7 d
Remarks on result:
positive indication of irritation
Irritant / corrosive response data:
Animals elicited slight to well-defined (one animal only) dermal reactions. All reactions had resolved by day 7.

Applicant's summary and conclusion