Registration Dossier
Registration Dossier
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EC number: 254-159-8 | CAS number: 38861-78-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- secondary source
- Title:
- IUCLID dataset for 38861-78-8
- Author:
- European Commission - European Chemicals Bureau
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- 1987
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1-[4-(2-methylpropyl)phenyl]ethan-1-one
- EC Number:
- 254-159-8
- EC Name:
- 1-[4-(2-methylpropyl)phenyl]ethan-1-one
- Cas Number:
- 38861-78-8
- Molecular formula:
- C12H16O
- IUPAC Name:
- 1-[4-(2-methylpropyl)phenyl]ethan-1-one
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- A single ocular dose
- Observation period (in vivo):
- Maximum of seven days
- Number of animals or in vitro replicates:
- Three
Results and discussion
In vivo
Results
- Irritation parameter:
- other: not specified
- Basis:
- mean
- Time point:
- 7 d
- Reversibility:
- fully reversible within: 7 d
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- Animals elicited temporary dulling of the cornea or corneal opacity and transient conjunctival irritation. All reactions had resolved two or seven days after installation.
Applicant's summary and conclusion
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