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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
secondary source
Title:
IUCLID dataset for 38861-78-8
Author:
European Commission - European Chemicals Bureau
Year:
2000
Report date:
2000

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Version / remarks:
1987
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1-[4-(2-methylpropyl)phenyl]ethan-1-one
EC Number:
254-159-8
EC Name:
1-[4-(2-methylpropyl)phenyl]ethan-1-one
Cas Number:
38861-78-8
Molecular formula:
C12H16O
IUPAC Name:
1-[4-(2-methylpropyl)phenyl]ethan-1-one

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
0.1 ml
Duration of treatment / exposure:
A single ocular dose
Observation period (in vivo):
Maximum of seven days
Number of animals or in vitro replicates:
Three

Results and discussion

In vivo

Results
Irritation parameter:
other: not specified
Basis:
mean
Time point:
7 d
Reversibility:
fully reversible within: 7 d
Remarks on result:
positive indication of irritation
Irritant / corrosive response data:
Animals elicited temporary dulling of the cornea or corneal opacity and transient conjunctival irritation. All reactions had resolved two or seven days after installation.

Applicant's summary and conclusion