Registration Dossier

Diss Factsheets

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
07 January 2010 to 26 February 2010
Reliability:
1 (reliable without restriction)
Qualifier:
according to guideline
Guideline:
other: Japan Bioaccumulation Tests of Chemical Substances in Fish/Shellfish Bodies for Test Methods for New Chemical Substances (Pharmaceutical and Food Safety Bureau 2003, Manufacturing Industries Bureau, 2003, Environ. Health Policy, 2006.
GLP compliance:
yes
Specific details on test material used for the study:
The test substance is listed as PPP or Pyridine, 4-(3-phenylpropyl) CAS # 2057-49-0.
Radiolabelling:
no
Vehicle:
no
Test organisms (species):
Cyprinus carpio
Details on test organisms:
The test organism, Cyprinus carpio,was obtained from Niikura Fish Farm on November 2, 2009 and were within 1 year after hatching.
Route of exposure:
aqueous
Test type:
flow-through
Water / sediment media type:
natural water: freshwater
Total exposure / uptake duration:
28 d
Test temperature:
24 ± 2˚C
pH:
6.0 to 8.5
Dissolved oxygen:
60% or greater of saturated dissolved oxygen concentration (5 mg/L or greater at 24 ˚C)
Nominal and measured concentrations:
The bioconcentration study evaluated the effects of the test substance with a high dose water concentration of 0.0005 mg/L and a low dose concentration of 0.00005 mg/L.
Reference substance (positive control):
no
Key result
Conc. / dose:
0.001 mg/L
Temp.:
>= 22 - <= 26 °C
pH:
6
Type:
BCF
Value:
28 L/kg
Basis:
not specified
Calculation basis:
steady state
Key result
Conc. / dose:
0 mg/L
Temp.:
>= 22 - <= 26 °C
pH:
6
Type:
BCF
Value:
92 L/kg
Basis:
not specified
Calculation basis:
steady state
Validity criteria fulfilled:
yes
Remarks:
All the items for validation of the test were satisfied, the test was determined to be valid.
Conclusions:
The BCF for the test substance was determined to be 28 L/kg at the high concentration tested (0.0005 mg/L) and 92 L/kg at the low concentration tested (0.00005 L/kg).

Description of key information

The key study was a carp bioaccumulation test conducted following the Japanese guideline for Bioaccumulation Tests of Chemical Substances in Fish/Shellfish Bodies for Test Methods for New Chemical Substances (Pharmaceutical and Food Safety Bureau Notice No. 1121002 dated November 21, 2003, Manufacturing Industries Bureau Notice No. 2 dated November 13, 2003, Environmental Health Policy Planning Division Notice No. 031121002, Final Amendment: November 20, 2006) and GLP standards. The BCF for the test substance was determined to be 28 L/kg ww at the high concentration tested (0.0005 mg/L) and 92 L/kg ww at the low concentration tested (0.00005 L/kg).

Key value for chemical safety assessment

BCF (aquatic species):
92 L/kg ww

Additional information