4-(3-phenylpropyl)pyridine

Bioaccumulation: aquatic / sediment

Link to relevant study record(s)

Reference

Endpoint:

bioaccumulation in aquatic species: fish

Type of information:

experimental study

Adequacy of study:

key study

Study period:

07 January 2010 to 26 February 2010

Reliability:

1 (reliable without restriction)

Qualifier:

according to guideline

Guideline:

other: Japan Bioaccumulation Tests of Chemical Substances in Fish/Shellfish Bodies for Test Methods for New Chemical Substances (Pharmaceutical and Food Safety Bureau 2003, Manufacturing Industries Bureau, 2003, Environ. Health Policy, 2006.

GLP compliance:

yes

Specific details on test material used for the study:

The test substance is listed as PPP or Pyridine, 4-(3-phenylpropyl) CAS # 2057-49-0.

Radiolabelling:

no

Vehicle:

no

Test organisms (species):

Cyprinus carpio

Details on test organisms:

The test organism, Cyprinus carpio,was obtained from Niikura Fish Farm on November 2, 2009 and were within 1 year after hatching.

Route of exposure:

aqueous

Test type:

flow-through

Water / sediment media type:

natural water: freshwater

Total exposure / uptake duration:

28 d

Test temperature:

24 ± 2˚C

pH:

6.0 to 8.5

Dissolved oxygen:

60% or greater of saturated dissolved oxygen concentration (5 mg/L or greater at 24 ˚C)

Nominal and measured concentrations:

The bioconcentration study evaluated the effects of the test substance with a high dose water concentration of 0.0005 mg/L and a low dose concentration of 0.00005 mg/L.

Reference substance (positive control):

no

Key result

Conc. / dose:

0.001 mg/L

Temp.:

>= 22 - <= 26 °C

pH:

6

Type:

BCF

Value:

28 L/kg

Basis:

not specified

Calculation basis:

steady state

Key result

Conc. / dose:

0 mg/L

Temp.:

>= 22 - <= 26 °C

pH:

6

Type:

BCF

Value:

92 L/kg

Basis:

not specified

Calculation basis:

steady state

Validity criteria fulfilled:

yes

Remarks:

All the items for validation of the test were satisfied, the test was determined to be valid.

Conclusions:

The BCF for the test substance was determined to be 28 L/kg at the high concentration tested (0.0005 mg/L) and 92 L/kg at the low concentration tested (0.00005 L/kg).

Description of key information

The key study was a carp bioaccumulation test conducted following the Japanese guideline for Bioaccumulation Tests of Chemical Substances in Fish/Shellfish Bodies for Test Methods for New Chemical Substances (Pharmaceutical and Food Safety Bureau Notice No. 1121002 dated November 21, 2003, Manufacturing Industries Bureau Notice No. 2 dated November 13, 2003, Environmental Health Policy Planning Division Notice No. 031121002, Final Amendment: November 20, 2006) and GLP standards. The BCF for the test substance was determined to be 28 L/kg ww at the high concentration tested (0.0005 mg/L) and 92 L/kg ww at the low concentration tested (0.00005 L/kg).

Key value for chemical safety assessment

BCF (aquatic species):

92 L/kg ww