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EC number: 274-393-4
CAS number: 70209-96-0
Scores when eyes were not rinsed
Days after application
Rabbit 4, male
Rabbit 5, male
Rabbit 6, male
Scores when eyes were rinsed
Rabbit 1, female
Rabbit 2, female
Rabbit 3, female
A study was performed to determine the eye
irritation potential of test item in rabbits. The procedure adopted was
the technique described in the "Appraisal of the Safety of Chemicals in
Foods, Drugs and Cosmetics (1959) of the US Association of Food and Drug
The substance was tested on 3 male and 3
female rabbits. Amounts of 0.1 g of the test substance were introduced
into the conjunctival sac of the left eye with a spatula. The treated
eyes of three rabbits were each rinsed with 10 ml lukewarm water about
30 seconds after treatment.
The total maximum is 80 for the cornea, 10
for the iris and 20 for the conjunctivae. The irritation index was found
to be 5.8 for the cornea, 0 the iris and 5 for the conjunctivae.
Discussion and conclusion
can be noted that in the study, 3 out of 6 animals did not receive
rinsing any time after the instillation of the test substance in eyes.
Not rinsing the treated eyes may lead to increased irritation response
and does not represent the real time scenarios of eyes of workers
getting exposed. Normally, any such incident will lead to rinsing of
eyes immediately. Hence, not rinsing of eyes is an elevated testing
condition and results normally do not have to be taken into account for
According to the EC classification of the
results obtained, the substance can be considered as non irritant to
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