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Physical & Chemical properties

Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
Version / remarks:
2008
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
-3.5
Temp.:
20 °C
pH:
>= 6.9 - <= 7
Key result
Type:
Pow
Partition coefficient:
0
Temp.:
20 °C
pH:
>= 6.9 - <= 7
Details on results:
Calculated partition coefficient (Pow) and logPow:
Ratio of solvents
(n-Octanol: Water) Pow Log Pow
1:1 0.00012* -3.9*
2:1 0.00036 -3.5
4:1 0.00034 -3.5
Mean all 0.00034 -3.5
Conclusions:
log Pow = -3.5
Executive summary:

The partition coefficient (Pow) of the test item was determined by the shake-flask method.

log Pow = -3.5

Pow = 0.00034

Description of key information

The partition coefficient (Pow) of the test item was determined by the shake-flask method.

log Pow = -3.5

Pow = 0.00034

Key value for chemical safety assessment

Log Kow (Log Pow):
-3.5
at the temperature of:
20 °C

Additional information