Registration Dossier
Registration Dossier
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EC number: 231-185-8 | CAS number: 7443-25-6
Endpoint summary
Administrative data
Description of key information
Hydrolysis: Half-life of 102 days at 12°C, pH 7
Biodegradation: Biodegradation of the submission substance: 17 % after 28 days
Adsorption / desorption: data waiving in accordance with column 2 of REACH Annex VIII
Additional information
Stability
Hydrolysis
In a reliable key study, hydrolysis as a function of pH was determined according to OECD 111 and in compliance with GLP (RL1). Hydrolysis reaction rate constants and half-lives were calculated from analysed samples based on a first order reaction kinetics model. The submission substance hydrolysed slowly (half-life t1/2 > 30 d) at pH 4 and 7 at 20 °C and moderately (2.4 h ≤ t1/2 ≤ 30 d) for the remaining test conditions (pH 4 at 30 and 50 °C, pH 7 at 30 and 50 °C as well as for pH 9 at 20, 30 and 50 °C). Half-lives were shorter in alkaline conditions (higher pH). The derived key value for exposure assessment was 102 days at 12°C, pH 7 (calculated acc. to ECHA guidance R.16). The submission substance is not expected to hydrolyse fast in the environment.
Biodegradation
Ready biodegradability
In a reliable key study, ready biodegradability of the submission substance was determined with a non-adapted activated sludge in the Manometric Respirometry Test for a period of 28 days (RL1). The test was performed according to OECD guideline 301 F and in compliance with GLP. After 28 days, the mean biodegradation was 17 %. The test item was classified as not readily biodegradable in the 10 d-window and after 28 days. The submission substance is not expected to biodegrade fast in the environment.
Transport and distribution
Adsorption / desorption
Due to the low octanol water partition coefficient, i.e. log Kow 2.4, the submission substance is not expected to adsorb to sludge, soil or sediment.
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