Registration Dossier
Registration Dossier
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EC number: 945-713-6 | CAS number: -
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Remarks:
- maximization test
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Fragrance raw materials monographs - alpha pinene
- Author:
- Opdyke DLJ
- Year:
- 1 978
- Bibliographic source:
- Food. Cosmet. Toxicol. (1978) 16, pp. 853-857
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- A maximization test (Kligman, 1966; Kligman & Epstein, 1975) was carried out on 25 volunteers.
No more data was provided on the method. - GLP compliance:
- no
- Type of study:
- other: maximization test
Test material
- Reference substance name:
- Pin-2(3)-ene
- EC Number:
- 201-291-9
- EC Name:
- Pin-2(3)-ene
- Cas Number:
- 80-56-8
- Molecular formula:
- C10H16
- IUPAC Name:
- 2,6,6-trimethylbicyclo[3.1.1]hept-2-ene
Constituent 1
In vivo test system
Test animals
- Species:
- other: human
- Strain:
- other: Not applicable
- Sex:
- not specified
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- 10 % in petrolatum
- Remarks on result:
- no indication of skin sensitisation
Any other information on results incl. tables
The material was tested at a concentration of 10 % in petrolatum and produced no sensitization reactions.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified (CLP Regulation EC no. 1272/2008)
- Conclusions:
- The material was tested on humans at a concentration of 10% in petrolatum and produced no sensitization reactions.
- Executive summary:
A maximization test was carried out on 25 volunteers. The material was tested at a concentration of 10% in petrolatum and produced no sensitization reactions.
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