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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Remarks:
maximization test
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
review article or handbook
Title:
Fragrance raw materials monographs - alpha pinene
Author:
Opdyke DLJ
Year:
1978
Bibliographic source:
Food. Cosmet. Toxicol. (1978) 16, pp. 853-857

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
A maximization test (Kligman, 1966; Kligman & Epstein, 1975) was carried out on 25 volunteers.
No more data was provided on the method.
GLP compliance:
no
Type of study:
other: maximization test

Test material

Constituent 1
Chemical structure
Reference substance name:
Pin-2(3)-ene
EC Number:
201-291-9
EC Name:
Pin-2(3)-ene
Cas Number:
80-56-8
Molecular formula:
C10H16
IUPAC Name:
2,6,6-trimethylbicyclo[3.1.1]hept-2-ene

In vivo test system

Test animals

Species:
other: human
Strain:
other: Not applicable
Sex:
not specified

Results and discussion

In vivo (non-LLNA)

Results
Reading:
1st reading
Group:
test chemical
Dose level:
10 % in petrolatum
Remarks on result:
no indication of skin sensitisation

Any other information on results incl. tables

The material was tested at a concentration of 10 % in petrolatum and produced no sensitization reactions.

Applicant's summary and conclusion

Interpretation of results:
other: Not classified (CLP Regulation EC no. 1272/2008)
Conclusions:
The material was tested on humans at a concentration of 10% in petrolatum and produced no sensitization reactions.
Executive summary:

A maximization test was carried out on 25 volunteers. The material was tested at a concentration of 10% in petrolatum and produced no sensitization reactions.

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