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EC number: 236-406-1 | CAS number: 13355-96-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
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- Nanomaterial pour density
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- Endpoint summary
- Stability
- Biodegradation
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- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Genetic toxicity
- Carcinogenicity
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- Specific investigations
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- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 7 February 2018 to 9 May 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
- Objective of study:
- other: hydrolysis as a function of pH
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- Butylhydroxyoxostannane
- EC Number:
- 218-880-1
- EC Name:
- Butylhydroxyoxostannane
- Cas Number:
- 2273-43-0
- Molecular formula:
- C4H10O2Sn
- IUPAC Name:
- butyl(oxo)stannanol
- Test material form:
- solid
- Details on test material:
- - Appearance: white solid
Constituent 1
- Radiolabelling:
- not specified
Results and discussion
Any other information on results incl. tables
HYDROLYSIS AT PH 4.0, 7.0, and 9.0:
- All samples did not show significant changes in the 119Sn-NMR Spectrum
- The half-life time of the substance under the conditions of the study was > 1 year.
- The substance is considered as hydrolytically stable at pH 4, 7, 9
- The signals propose a dimeric tetraorganodistannoxane structure. Those structures are formed following a stepwise hydrolysis of initially formed diorganotin hydroxides.
HYDROLYSIS AT PH 1.2
- The 119Sn-NMR spectrum of the organic extract shows a decrease of the products peak and an increase of the breakdown product, the monochloride of the substance DOT(-Neo)Cl.
- The 119Sn-NMR spectrum shows only one signal in pH 1.2 not any longer the typical signal for dimeric MBTO (distannoxane). The single signal can be assigned to monomeric monobutylstannonic acid.
Applicant's summary and conclusion
- Conclusions:
- The study shows that the test material is hydrolytically stable at pH 4, 7, 9. After 5 days of hydrolysis at 50°C less than 10% of the test material was hydrolysed (half life at 25°C > 1 year).
Under simulated gastric conditions (0.1 M HCl /pH 1.2 /40°C/ 4 h) the 119Sn-NMR spectrum shows only one signal in pH 1.2 not any longer the typical signal for dimeric MBTO (distannoxane). The single signal can be assigned to monomeric monobutylstannonic acid. - Executive summary:
The hydrolysis of the test material as a function of pH was investigated in accordance with the standardised guidelines OECD 111 and EU Method C.7.
The stability of the test material was investigated at pH 4, 7 and 9 and pH 1.2 using NMR spectroscopy.
The study shows that the test material is hydrolytically stable at pH 4, 7, 9. After 5 days of hydrolysis at 50°C less than 10% of the test material was hydrolysed (half life at 25°C > 1 year).
Under simulated gastric conditions (0.1 M HCl /pH 1.2 /40°C/ 4 h) the 119Sn-NMR spectrum shows only one signal in pH 1.2 not any longer the typical signal for dimeric MBTO (distannoxane). The single signal can be assigned to monomeric monobutylstannonic acid.
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