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EC number: 231-672-5 | CAS number: 7681-55-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
The Merck Index, Cosmetic Ingredient review, Lent et al (2017)
The acute oral LD50 of the substance to mice was reported to be 505 mg/kg.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- not stated
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Groups of 10 fasted female white Swiss mice received test material orally. They were observed for two weeks following dosing and underwent necropsy.
Review references Webster et al. 1957 (Webster SH, Rice ME, Highman B, Von Oettingen WF (1957) The toxicology of potassium and sodium iodates: acute toxicity in mice. J Pharmacol Exp Ther 120: 171-8) - GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
- Specific details on test material used for the study:
- - 6 %
- Species:
- mouse
- Strain:
- Swiss
- Route of administration:
- oral: unspecified
- No. of animals per sex per dose:
- 10 females per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes - Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 505 mg/kg bw
- Based on:
- not specified
- Interpretation of results:
- other: Category 4 according to EU criteria
- Conclusions:
- Under the conditions of the study the acute oral LD50 of the test material to female Swiss mice was 505 mg/kg.
- Executive summary:
Groups of 10 fasted female white Swiss mice received test material orally. They were observed for two weeks following dosing and underwent necropsy.
Signs of intoxication included diarrhoea, alternate hyperactivity and lassitude, followed by weakness, prostration, and dyspnea. At higher doses, death was often preceded by excitability and convulsions. Haemoglobinuria occurred in many of the animals. Animals that survived 2 weeks following dosing underwent necropsy. At microscopic examination, lesions, such as degeneration of many parietal cells of the gastric glands, were observed in animals dosed with 463 mg/kg test material.
Under the conditions of the study the acute oral LD50 of the test material to female Swiss mice was 505 mg/kg.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- not specified
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Effects following acute oral exposure to female mice are reported.
- GLP compliance:
- not specified
- Remarks:
- GLP compliance not specified in publication
- Species:
- mouse
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 505 mg/kg bw
- Based on:
- not specified
- Interpretation of results:
- other: Category 4 according to EU criteria
- Conclusions:
- The acute oral LD50 of the test material to mice is reported to be 505 mg/kg.
- Executive summary:
The acute oral LD50 of the test material to mice is reported to be 505 mg/kg.
Reported effects of sodium iodate and potassium iodate oral exposure included alternate hyperactivity and lassitude, weakness, prostration, dyspnea, and diarrhoea. Transient increases in gastrointestinal pH and degeneration of parietal cells, haemolytic effects including haemoglobinuria and haemosiderin deposits in the kidneys were observed. Mortality was attributed to renal damage.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- not stated
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Valid with restrictions. This is peer reviewed data where the test methodology and identity of the substance have been evaluated, and a reliable and representative value for the endpoint has been selected. No information on GLP status or test guideline followed is available.
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Handbook data does not specify the method. Data from peer reviewed source.
- GLP compliance:
- not specified
- Test type:
- other: Handbook data does not specify the method. Data from peer reviewed source.
- Species:
- mouse
- Sex:
- female
- Route of administration:
- oral: unspecified
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 505 mg/kg bw
- Based on:
- not specified
- Interpretation of results:
- other: Category 4 according to EU criteria
- Conclusions:
- According to the handbook data the acute oral LD50 of the test material to female mice is 505 ± 26 mg/kg.
- Executive summary:
According to the handbook data the acute oral LD50 of the test material to female mice is 505 ± 26 mg/kg.
Referenceopen allclose all
Signs of intoxication included diarrhoea, alternate hyperactivity and lassitude, followed by weakness, prostration, and dyspnea. At higher doses, death was often preceded by excitability and convulsions. Haemoglobinuria occurred in many of the animals. Animals that survived 2 weeks following dosing underwent necropsy. At microscopic examination, lesions, such as degeneration of many parietal cells of the gastric glands, were observed in animals dosed with 463 mg/kg test material.
Reported effects of sodium iodate and potassium iodate oral exposure included alternate hyperactivity and lassitude, weakness, prostration, dyspnea, and diarrhoea. Transient increases in gastrointestinal pH and degeneration of parietal cells, haemolytic effects including haemoglobinuria and haemosiderin deposits in the kidneys were observed. Mortality was attributed to renal damage.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 505 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute Oral Toxicity
The Merck Index
According to the handbook data the acute oral LD50 of the test material to female mice is 505 ± 26 mg/kg.
Cosmetic Ingredient Review
Groups of 10 fasted female white Swiss mice received test material orally. They were observed for two weeks following dosing and underwent necropsy.
Signs of intoxication included diarrhea, alternate hyperactivity and lassitude, followed by weakness, prostration, and dyspnea. At higher doses, death was often preceded by excitability and convulsions. Hemoglobinuria occurred in many of the animals. Animals that survived 2 weeks following dosing underwent necropsy. At microscopic examination, lesions, such as degeneration of many parietal cells of the gastric glands, were observed in animals dosed with 463 mg/kg test material.
Under the conditions of the study the acute oral LD50 of the test material to female Swiss mice was 505 mg/kg.
Lent et al. (2017)
The acute oral LD50 of the test material to mice is reported to be 505 mg/kg.
Reported effects of sodium iodate and potassium iodate oral exposure included alternate hyperactivity and lassitude, weakness, prostration, dyspnea, and diarrhea. Transient increases in gastrointestinal pH and degeneration of parietal cells, hemolytic effects including hemoglobinuria and hemosiderin deposits in the kidneys were observed. Mortality was attributed to renal damage.
Murray (1953)
The test material was dosed to groups of 10 mice at dose levels of 250, 750 and 2500 mg/kg bw.
No symptoms were reported in the group dosed at 250 mg/kg bw. At the dose level of 750 mg/kg bw 7 of the 10 animals died within 3 weeks. At 2500 mg/kg bw all of the animals died within 12 hours.
Justification for classification or non-classification
In accordance with the criteria for classification as defined in Annex I, Regulation (EC) No 1272/2008, the substance requires classification for acute oral toxicity (category 4) and is assigned the hazard statement "H302: Harmful if swallowed".
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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