Propanamide, N-[2-(4-phenoxyphenoxy)ethyl]-

Endpoint summary

Description of key information

Supporting evidence of absence of skin and eye irritation properties.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records

Reference

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1987

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

significant methodological deficiencies

Qualifier:

no guideline followed

Principles of method if other than guideline:

A group of 3 adult Wistar rats was applied 0.4 mL of the test item at 20% (w/v) in DMSO on a 4 cm² of shaved skin once on one area and twice at one day's interval on another area without covering.

GLP compliance:

no

Specific details on test material used for the study:

Appearance: brown-beige solid
Test item name (as cited in the report): para phenoxy phenoxy ethyl propionamid
Molecular weight: 286
Melting point: 110 °C
Not soluble in water, PEG400 and oilve oil

Species:

rat

Strain:

Wistar

Details on test animals or test system and environmental conditions:

Initial weight: 300-350 g
Housed in groups of 3

Type of coverage:

open

Preparation of test site:

shaved

Vehicle:

other: DMSO

Controls:

no

Amount / concentration applied:

0.4 mL of solution of test item in DMSO (20% (w/v))

Duration of treatment / exposure:

Area 1: one application on Day 1
Area 2: one application on Day 1 and another application on Day 2

Number of animals:

3/group

Details on study design:

TEST SITE
- Area of exposure: 4 cm²

SCORING SYSTEM:
- Method of calculation: 4 grades of lesions
0: no reaction
1: Transcient simple redness
2: Redness + edema without/without crusts with reversibility
3: necrosis with eschar leading to premature sacrifice of the animal

Irritation parameter:

overall irritation score

Basis:

mean

Score:

0

Max. score:

4

Reversibility:

other: not applicable

Remarks on result:

no indication of irritation

Interpretation of results:

study cannot be used for classification

Conclusions:

Under the test conditions, the test item at 20% (w/v) in DMSO is not irritating to the skin.

Executive summary:

A group of 3 adult Wistar rats was applied 0.4 mL of the test item at 20% (w/v) in DMSO on a 4 cm² of shaved skin once on one area and twice at one day's interval on another area. The sites of application were not covered and the animals were restrained during a few minutes, until the solution was visually absorbed by the skin. At the time of reading, the substance did not show any signs of irritation.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records

Reference

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1987

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

significant methodological deficiencies

Qualifier:

no guideline followed

Principles of method if other than guideline:

One drop of a 20% solution diluted at 1/100 was instilled in the eye of 3 male Wistar rats

GLP compliance:

no

Specific details on test material used for the study:

Appearance: brown-beige solid
Test item name (as cited in the report): para phenoxy phenoxy ethyl propionamid
Molecular weight: 286
Melting point: 110 °C
Not soluble in water, PEG400 and oilve oil

Species:

rat

Strain:

Wistar

Details on test animals or tissues and environmental conditions:

Initial weight: 300-350 g

Vehicle:

other: DMSO

Controls:

yes, concurrent no treatment

Amount / concentration applied:

One drop of a 20% (w/v) solution diluted at 1/100

Duration of treatment / exposure:

Not applicable

Observation period (in vivo):

No data

Number of animals or in vitro replicates:

3

Details on study design:

No data

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

other: no data

Score:

0

Reversibility:

other: not applicable

Remarks on result:

no indication of irritation

Interpretation of results:

study cannot be used for classification

Conclusions:

Under the test conditions, the test item did not show any signs of eye irritation.

Executive summary:

One drop of a 20% (w/v) solution of test item in DMSO, diluted at 1/100, was instilled in the eye of 3 male Wistar rats. No signs of irritation were recorded.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

A group of 3 adult Wistar rats was applied 0.4 mL of the test item at 20% (w/v) in DMSO on a 4 cm² of shaved skin once on one area and twice at one day's interval on another area. The sites of application were not covered and the animals were restrained during a few minutes, until the solution was visually absorbed by the skin. At the time of reading, the substance did not show any signs of irritation.

One drop of a 20% (w/v) solution of test item in DMSO, diluted at 1/100, was instilled in the eye of 3 male Wistar rats. No signs of irritation were recorded.

Justification for classification or non-classification

Although the substance was not tested undiluted, available data show supporting evidence that the registered substance may not have skin or eye irritation properties.