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Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1987
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
significant methodological deficiencies

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987
Report date:
1987

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
One drop of a 20% solution diluted at 1/100 was instilled in the eye of 3 male Wistar rats
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
N-[2-(4-phenoxyphenoxy)ethyl]propanamide
EC Number:
600-606-0
Cas Number:
104825-66-3
Molecular formula:
C17H19NO3
IUPAC Name:
N-[2-(4-phenoxyphenoxy)ethyl]propanamide
Test material form:
solid
Details on test material:
Appearance: brown-beige solid
Molecular weight: 286
Melting point: 110 °C
Not soluble in water, PEG400 and oilve oil
Specific details on test material used for the study:
Appearance: brown-beige solid
Test item name (as cited in the report): para phenoxy phenoxy ethyl propionamid
Molecular weight: 286
Melting point: 110 °C
Not soluble in water, PEG400 and oilve oil

Test animals / tissue source

Species:
rat
Strain:
Wistar
Details on test animals or tissues and environmental conditions:
Initial weight: 300-350 g

Test system

Vehicle:
other: DMSO
Controls:
yes, concurrent no treatment
Amount / concentration applied:
One drop of a 20% (w/v) solution diluted at 1/100
Duration of treatment / exposure:
Not applicable
Observation period (in vivo):
No data
Number of animals or in vitro replicates:
3
Details on study design:
No data

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: no data
Score:
0
Reversibility:
other: not applicable
Remarks on result:
no indication of irritation

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
Under the test conditions, the test item did not show any signs of eye irritation.
Executive summary:

One drop of a 20% (w/v) solution of test item in DMSO, diluted at 1/100, was instilled in the eye of 3 male Wistar rats. No signs of irritation were recorded.