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EC number: 945-888-9 | CAS number: -
- The mean absolute OD570of the three negative control tissues was ≥0.8 and ≤ 2.8 (1.907)
- The mean relative tissue viability (% negative control) of the positive control was ≤ 20% (3.1%)
- Standard deviation of viability of replicate tissues of all dose groups was ≤ 18% (0.2% - 5.3%)
Table 1: Mean Relative Tissue Viability for the test item
Mean Relative Tissue Viability [%]
In a primary skin irritation study conducted according to the guideline OECD 439, 25 mg of Ytterbium stabilized Zirconium and Hafnium Oxide (Purity > 95 %) was topically applied to the EpiDerm tissue for 60 min followed by a 42 h post-incubation period. Irritant potential of the test item was predicted from the relative mean tissue viabilities obtained compared to the corresponding negative control tissues concurrently treated with DPBS. The controls confirmed the validity of the study. The mean relative tissue viability (% negative control) was observed to be > 50% (92.8%). Based on these results, the test item is classified as a non-irritant under the UN GHS Criteria.
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