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EC number: 218-080-2
CAS number: 2050-08-0
Skin irritation: Non irritating to skin in vitro (Episkin method)Eye irritation: Not corrosive to eyes or a severe irritant to eyes in vitro (BCOP); Not a mild nor a moderate irritant to rabbits eye based on read across to structural analogue, Cyclohexyl salicylate
endpoints as part of the REACH registration of the REACH registration of
Amyl Salicylate (Target
Substance) it is proposed to
read-across to Cyclohexyl Salicylate (Source
use of read-across works within the spirit of REACH and the stated aim
of the legislation to reduce animal testing where possible.
Substance and Source
Substance have been characterised
using the categories and databases present in the OECD [Q]SAR Toolbox. From
the profiling, it can be seen that the two substances share structural
similarities and also ‘mechanistic action’ similarities which are both
general and endpoint specific.
classification purposes this demonstrates that read across is valid and
Amyl salicylate is not classified in accordance with CLP based on the
Source substance, Cyclohexyl salicylate also not being classified.
The test substance was assessed for skin and eye irritation. There was
no potential for skin irritation (Episkin
Furthermore, the substance is not
corrosive to eyes or a severe irritant to eyes in vitro (BCOP); Not a
mild nor a moderate irritant to rabbits eye based on read across to
structural analogue, Cyclohexyl salicylate and classification in
accordance with Regulation (EC) No. 1272/2008 (CLP) or in
accordance with Regulation 67/548/EEC is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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