Registration Dossier
Registration Dossier
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EC number: 218-080-2 | CAS number: 2050-08-0
Endpoint summary
Administrative data
Description of key information
Skin irritation: Non irritating to skin in vitro (Episkin method)
Eye irritation: Not corrosive to eyes or a severe irritant to eyes in vitro (BCOP); Not a mild nor a moderate irritant to rabbits eye based on read across to structural analogue, Cyclohexyl salicylate
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
To address toxicological endpoints as part of the REACH registration of the REACH registration of Amyl Salicylate (Target Substance) it is proposed to read-across to Cyclohexyl Salicylate (Source Substance).
The use of read-across works within the spirit of REACH and the stated aim of the legislation to reduce animal testing where possible.
The Target Substance and Source Substance have been characterised using the categories and databases present in the OECD [Q]SAR Toolbox. From the profiling, it can be seen that the two substances share structural similarities and also ‘mechanistic action’ similarities which are both general and endpoint specific.
For classification purposes this demonstrates that read across is valid and Amyl salicylate is not classified in accordance with CLP based on the Source substance, Cyclohexyl salicylate also not being classified.
Justification for classification or non-classification
The test substance was assessed for skin and eye irritation. There was no potential for skin irritation (Episkin method)
within the framework of Regulation (EC) No. 1272/2008 (CLP) or in accordance with Regulation 67/548/EEC.Furthermore, the substance is not corrosive to eyes or a severe irritant to eyes in vitro (BCOP); Not a mild nor a moderate irritant to rabbits eye based on read across to structural analogue, Cyclohexyl salicylate and classification in accordance with Regulation (EC) No. 1272/2008 (CLP) or in accordance with Regulation 67/548/EEC is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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