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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Dissociation constant

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Administrative data

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Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: GLP guideline study, solvent used, therefore results are not so accurate
Qualifier:
according to guideline
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
GLP compliance:
yes
Specific details on test material used for the study:
The test was performed with 2-phenylphenol, the conjugate acid of sodium 2-biphenylate.
99.9 % 2-phenylphenol
No.:
#1
pKa:
11.4
Remarks on result:
other: No temperature control. As about 30 % acetone was added to increase the solubility of the test substance, the received pKa value was higher than the one determined in demineralized water in study no.: A 89/0062/06 LEV
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
GLP compliance:
yes
Specific details on test material used for the study:
The test was performed with 2-phenylphenol, the conjugate acid of sodium 2-biphenylate.
99.89 % 2-phenylphenol
Dissociating properties:
yes
pKa:
9.5
Temp.:
20 °C
Remarks on result:
other: Acid-base constant: pKa = 9.5 ± 0.1

Description of key information

pKa (2-phenylphenol) = 9.5 at 20 °C

(OECD 112)

Key value for chemical safety assessment

pKa at 20°C:
9.5

Additional information

A pKa value of 9.5 at 20 °C was determined for 2-phenylphenol (conjugate acid of sodium 2-biphenylate) during tests according to OECD Guideline 112. A pKa value of 11.4 was determined in a different study during tests according to OECD Guideline 112. The difference between the two measured values could be attributed to the use of solvent in the second study.