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Administrative data

Endpoint:
activated sludge respiration inhibition testing
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Not assignable data from the SIDS report on Long Chain Alcohols

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
2006

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Various tests on inhibition of bacterial cell growth. Pseudomonas putida: DIN 38412, Teil 27 (Bacterial oxygen consumption test)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Tetradecanol
EC Number:
204-000-3
EC Name:
Tetradecanol
Cas Number:
112-72-1
Molecular formula:
C14H30O
IUPAC Name:
tetradecan-1-ol
Test material form:
not specified
Details on test material:
Not specified.

Sampling and analysis

Analytical monitoring:
no

Test solutions

Vehicle:
not specified
Details on test solutions:
In some tests a vehicle was used (e.g. ethanol) in others the test substance was added as such.

Test organisms

Test organisms (species):
other: Streptococcus mutans MT 5091; Pseudomonas putida; Tetrahymena pyriformis; Clostridium botulinum; Mycoplasma gallisepticum; Mycoplasma pneumoniae; Streptococcus mutans; Candida 107; Candida tropicalis; Saccharomyces carlsbergensis

Study design

Test type:
static
Water media type:
freshwater
Limit test:
no
Remarks on exposure duration:
Test duration varied from 30 minutes (Pseudomonas putida) to 144 hours (cell growth inhibition tests).

Results and discussion

Effect concentrationsopen allclose all
Duration:
48 h
Dose descriptor:
other: Minimal Inhibitory Concentration
Effect conc.:
1.56 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Remarks on result:
other: Species: Streptococcus mutans MT 5091
Duration:
30 min
Dose descriptor:
other: EL0
Effect conc.:
10 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate
Remarks on result:
other: Species: Pseudomonas putida
Duration:
48 h
Dose descriptor:
NOEC
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Remarks on result:
other: No effect at level of saturation (no loading rate specified), Species: Tetrahymena pyriformis
Dose descriptor:
other: Minimal Inhibitory Concentration
Effect conc.:
0.6 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Remarks on result:
other: No data on duration, Species: Clostridium botulinum
Duration:
144 h
Dose descriptor:
NOEC
Effect conc.:
13.7 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Remarks on result:
other: Species: Mycoplasma pneumoniae
Duration:
24 h
Dose descriptor:
EC50
Effect conc.:
> 2.7 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Remarks on result:
other: Species: Streptococcus mutans
Duration:
72 h
Dose descriptor:
EC0
Effect conc.:
82.4 g/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Remarks on result:
other: Species: Candida 107; Candida tropicalis; Saccharomyces carlsbergensis

Applicant's summary and conclusion

Validity criteria fulfilled:
not specified
Conclusions:
In general, tetradecanol has no effect on the activity or growth of microorganisms at levels above the water solubility.

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