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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1977- no more details available
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
no data available
GLP compliance:
not specified
Test type:
other: no information available
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
α-acetyl-γ-butyrolactone
EC Number:
208-235-2
EC Name:
α-acetyl-γ-butyrolactone
Cas Number:
517-23-7
Molecular formula:
C6H8O3
IUPAC Name:
α-acetyl-γ-butyrolactone
Specific details on test material used for the study:
No data

Test animals

Species:
mouse
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
No data

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
No data
Doses:
No data
No. of animals per sex per dose:
10
Control animals:
not specified
Details on study design:
No data
Statistics:
No data

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LD50
Effect level:
8 500 mg/kg bw
Remarks on result:
other: after 10 days
Sex:
male/female
Dose descriptor:
other: LD10
Effect level:
6 700 mg/kg bw
Remarks on result:
other: after 10 days
Sex:
male/female
Dose descriptor:
other: LD90
Effect level:
10 600 mg/kg bw
Remarks on result:
other: after 10 days
Mortality:
No data
Clinical signs:
No data
Body weight:
No data
Gross pathology:
No data

Any other information on results incl. tables

The tests were carried out by using 10 animals per dosage group. The routes of adninistration were oral (by gavage). The lethal doses were determined by the computer method developed by Dr S. Wolf. The LD 10, LD 50, and LD 90 are stated for observation periods of 24 hours and of 10 days. The LD 50 value for A-Lactone was found to be 8500 mg/kg bw (after 10 days).

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Substance is not toxic