Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
eye irritation, other
Remarks:
information derived from published data
Type of information:
other: information derived from published data
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
review article or handbook
Title:
GESTIS Substance Database 1,3-Dichloropropane
Author:
IFA Institue for Occupational Safety and Health of the German Social Accident Insurance
Year:
2018
Bibliographic source:
http://gestis-en.itrust.de/pdf/create/Data_sheet.php

Materials and methods

Principles of method if other than guideline:
observation by professionals, including Biomonitoring and adminstrative measures
GLP compliance:
not specified
Remarks:
assumed to be GLP

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-dichloropropane
EC Number:
205-531-3
EC Name:
1,3-dichloropropane
Cas Number:
142-28-9
Molecular formula:
C3H6Cl2
IUPAC Name:
1,3-dichloropropane
Test material form:
liquid
Specific details on test material used for the study:
no data available

Test animals / tissue source

Species:
other: Homo sapiens
Strain:
not specified
Details on test animals or tissues and environmental conditions:
cohort is professional workers

Test system

Vehicle:
unchanged (no vehicle)
Duration of treatment / exposure:
irregular, max. 10 h/d
Number of animals or in vitro replicates:
cohort is small because no full registration in EU so far

Results and discussion

In vitro

Results
Irritation parameter:
other: irritation by exposure of eyes to workplace air
Run / experiment:
daily work, assumed to be 8 h per 5d week and 48 w/year
Remarks on result:
not determinable because of methodological limitations
Remarks:
no measured workplace concentrations available

In vivo

Irritant / corrosive response data:
GESTIS: "Manufacturers indicate that the liquid triggers moderate irritations to the eyes, but does not cause any severe or persistent damage."

Applicant's summary and conclusion

Interpretation of results:
other: data cannot be used for classification and the classification of the GESTIS is followed
Conclusions:
"Manufacturers indicate that the liquid triggers moderate irritations to the eyes, but does not cause any severe or persistent damage."
The classification reported in GESTIS is: Eye irritation, Category 2; H319 Causes serious eye irritation.
Executive summary:

Eye irritation, Category 2; H319